• Publications
  • Influence
Toll‐like receptor stimulation induces airway hyper‐responsiveness to bradykinin, an effect mediated by JNK and NF‐κB signaling pathways
Airway infections induce hyper‐responsiveness in asthmatic patients. Toll‐like receptors (TLR) mediate inflammatory responses to microbes. Occurrence and effects of TLR2, TLR3 and TLR4 were examinedExpand
  • 87
  • 3
Lactobacillus-Mediated Priming of the Respiratory Mucosa Protects against Lethal Pneumovirus Infection
The inflammatory response to respiratory virus infection can be complex and refractory to standard therapy. Lactobacilli, when targeted to the respiratory epithelium, are highly effective atExpand
  • 76
  • 3
Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathways.
Airway infections induce hyper-responsiveness in asthmatic patients. Toll-like receptors (TLR) mediate inflammatory responses to microbes. Occurrence and effects of TLR2, TLR3 and TLR4 were examinedExpand
  • 43
  • 3
TNFα reduces tachykinin, PGE2‐dependent, relaxation of the cultured mouse trachea by increasing the activity of COX‐2
1 Chronic inflammation is a central feature of asthma. The inflammatory cytokine tumour necrosis factor α (TNFα) has been implicated in this disease, and is known to alter airway smooth muscleExpand
  • 19
  • 2
Nerve growth factor enhances cholinergic innervation and contractile response to electric field stimulation in a murine in vitro model of chronic asthma
Background Asthma is a chronic inflammatory disease characterized by airway hyper‐responsiveness. Alterations in the neurogenic control are believed to contribute to the pathogenesis. Yet, theExpand
  • 28
  • 1
Nasal CpG oligodeoxynucleotide administration induces a local inflammatory response in nonallergic individuals
Background:  We have previously demonstrated the presence of toll‐like receptor 9 in the nasal mucosa of both healthy and allergic individuals. CpG motifs, found in bacterial and viral DNA, elicitExpand
  • 14
Lipopolysaccharide administration to the allergic nose contributes to lower airway inflammation
Background Allergic rhinitis (AR) is an inflammatory reaction not confined to a single local compartment, but rather involving the whole airway system. Allergens known to induce AR are not always theExpand
  • 12
Leukocyte phenotype changes induced by specific immunotherapy in patients with birch allergy.
BACKGROUND The underlying mechanisms of allergen-specific immunotherapy (SIT) are not fully understood. OBJECTIVES The present study aimed to investigate how leukocyte phenotypes are affected byExpand
  • 7
  • Open Access
Prolonged exposure to NT-3 attenuates cholinergic nerve-mediated contractions in cultured murine airways
Chronic airway inflammation may induce subsequent airway hyper-responsiveness (AHR) including pathological alteration of neural activity. Asthmatic airways contain elevated levels of neurotrophin-3Expand
  • 6
  • Open Access
Toll-like receptor activation in airway smooth muscle: dual actions via separate MAPK pathways.
airway infections of viral or bacterial origin are a common cause of respiratory disease. Infection is also a well-known reason for asthmatic exacerbations ([4][1]). Therefore, increased insights inExpand
  • 8
  • Open Access