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Sequential phases of cortical specification involve Neurogenin‐dependent and ‐independent pathways
TLDR
It is demonstrated that distinct genetic programs operate at different stages of corticogenesis to specify the properties shared by all neocortical neurons.
Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.
TLDR
It is proposed that Mash1 synergizes with Brn factors to regulate multiple steps of neurogenesis, and a number of additional candidate target genes are identified, recognized by Mash1 and Brn proteins through a DNA-binding motif similar to that found in the Delta1 gene and present a broad range of activities.
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2
TLDR
This work shows that the proneural protein neurogenin 2 (Neurog2), which controls neurogenesis in the embryonic cerebral cortex, directly induces the expression of the small GTP-binding protein Rnd2 in newly generated mouse cortical neurons before they initiate migration.
Two independent transcription initiation codes overlap on vertebrate core promoters
TLDR
It is shown that the transition from the maternal to zygotic transcriptome is characterized by a switch between two fundamentally different modes of defining transcription initiation, which drive the dynamic change of TSS usage and promoter shape.
Characterization of the proneural gene regulatory network during mouse telencephalon development
TLDR
Together, these data shed light on the molecular pathways regulated by proneural genes and demonstrate that the integration of experimentation with bioinformatics can guide both hypothesis testing and hypothesis generation.
Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival
TLDR
The results imply that Spry2 is involved in the development of the CNS by inhibiting both neuronal differentiation and survival through a negative-feedback loop that downregulates neurotrophic factors-driven signaling pathways.
Dynamic regulation of the transcription initiation landscape at single nucleotide resolution during vertebrate embryogenesis.
TLDR
A first and comprehensive description of the core promoter repertoire and its dynamic use during the development of a vertebrate embryo is provided, by using cap analysis of gene expression (CAGE) to reveal genome-wide rules of core promoter usage, structure, and dynamics.
The Light Responsive Transcriptome of the Zebrafish: Function and Regulation
TLDR
Light induced gene transcription in the zebrafish is characterized at several organizational levels and Morpholino-mediated knock-down studies of two homologues of the D-box binding factor Tef indicate that these are differentially involved in the cell autonomous light induction in a gene-specific manner.
Fungi use the SakA (HogA) pathway for phytochrome-dependent light signalling
TLDR
It is shown that phytochrome-dependent light signalling in Aspergillus nidulans involves the stress-sensing and osmosensing signalling pathway and can be considered to be a hub for environmental signals.
Gene responses in the central nervous system of zebrafish embryos exposed to the neurotoxicant methyl mercury.
TLDR
It is proposed that MeHg disturbs the function of the CNS by disturbing the cellular homeostasis as these cellular stress responses comprise genes that are also involved in normal neuronal activity and learning, and may affect the developing CNS in a subtle manner that manifests itself in behavioral deficits.
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