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Disposition and retention of mercuric chloride in mice after oral and parenteral administration.
- J. Nielsen, O. Andersen
- Chemistry, MedicineJournal of toxicology and environmental health
- 1 July 1990
The present study compares effects of dose size on whole-body retention and relative organ distribution of 203HgCl2, after oral and intraperitoneal administration to female mice of two strains…
Methyl mercuric chloride toxicokinetics in mice. I: Effects of strain, sex, route of administration and dose.
The elimination of mercury was demonstrated to follow first order kinetics during the two week study period independently of administration route, strain or sex, and an inverse relationship between administered dose and whole-body retention was observed and by indirect evidence demonstrated not to be caused by an effect on the intestinal uptake mechanism.
Oral cadmium chloride intoxication in mice: effects of dose on tissue damage, intestinal absorption and relative organ distribution.
The delayed fecal elimination and increased fractional absorption of Cadmium may significantly contribute to the development of both local and systemic toxicity in oral cadmium intoxication.
Experimental localization of intestinal uptake sites for metals (Cd, Hg, Zn, Se) in vivo in mice.
- O. Andersen, J. B. Nielsen, J. A. Sørensen, L. Scherrebeck
- Chemistry, MedicineEnvironmental health perspectives
- 1 September 1994
Using gamma-emitting metal isotopes, in vivo labeling profiles of the intestinal tract were obtained from mice eating their normal diet and indicated that intestinal uptake processes were in fact studied.
Interaction of cadmium ions with calcium hydroxyapatite crystals: a possible mechanism contributing to the pathogenesis of cadmium-induced bone diseases
- J. Christoffersen, M. Christoffersen, +4 authors P. Grandjean
- Chemistry, MedicineCalcified Tissue International
- 1 May 1988
Cadmium ions adsorb onto calcium hydroxyapatite crystals and are as effective as inorganic pyrophosphate and aluminum ions in retarding the rate of in vitro dissolution of HA, thus making them very resistant to subsequent dissolution.
Oral cadmium exposure in mice: toxicokinetics and efficiency of chelating agents.
- O. Andersen
- Chemistry, MedicineCritical reviews in toxicology
on the acute toxicity of metals have been reviewed by Aaseth,’ B~lman,~~ Catsch and Harm~th-Hoene,~~ Jones,’I4 May and B~lman,’~~ and specifically for cadmium by Andersen6 and Nordberg.’@ In most of…
Effects of liver damage induced by polychlorinated biphenyls (PCB) on cadmium metabolism in mice.
- O. Andersen, P. Lindegaard, M. Unger, G. Nordberg
- Chemistry, MedicineEnvironmental research
- 1 December 1985
The results support observations made with agents inducing acute liver damage, that liver damage increases the rate of redistribution of cadmium from the liver to the kidney and suggests a faster transport of Cd from liver to kidneys in PCB-exposed animals than in controls.
Oral cadmium chloride intoxication in mice: effects of penicillamine, dimercaptosuccinic acid and related compounds.
This study indicates that, in oral cadmium intoxication in humans, orally administered DMSA would be likely to offer protection against the local toxicity of cadmiam in the gastrointestinal tract as well as to reduce the risk of systemic toxicity of absorbed Cadmium.
Nutritional interactions in intestinal cadmium uptake - Possibilities for risk reduction
Effects of dietary composition and trace element status on fractional intestinal cadmium uptake is reviewed below and assurance of optimal trace elements status in persons exposed to cadmiam is essential for risk reduction.
Methyl mercuric chloride toxicokinetics in mice. II: Sexual differences in whole-body retention and deposition in blood, hair, skin, muscles and fat.
The elimination of mercury from carcass was slower than the elimination from the whole-body, causing an increasing relative carcass deposition with time in both male and female mice and explaining the observed deviation from first order elimination kinetics.