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Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up.
An incidence cohort consisting of 308 multiple sclerosis patients was followed up repeatedly during at least 25 years of disease. A number of clinical factors were analysed with respect to theirExpand
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ETFDH mutations as a major cause of riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency.
Multiple acyl-CoA dehydrogenation deficiency (MADD) is a disorder of fatty acid, amino acid and choline metabolism that can result from defects in two flavoproteins, electron transfer flavoproteinExpand
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Long-term follow up of patients with clinically isolated syndromes, relapsing-remitting and secondary progressive multiple sclerosis
This paper extends on previous data on prognosis in multiple sclerosis (MS), to encompass the entire course of the disease. The first episode suggestive of MS [the clinically isolated syndrome (CIS)]Expand
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Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis
The neurofilament protein is a major structural protein of neurons and a marker for axonal damage. The concentrations of the light subunit of the neurofilament triplet protein (NFL) in CSF wereExpand
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Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study
A neurological surveillance was combined with prospective recording of upper respiratory and gastrointestinal infections and serological diagnosis of five common viral infections in 60 benignExpand
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MRI characteristics and scoring in HDLS due to CSF1R gene mutations
Objective: To describe the brain MRI characteristics of hereditary diffuse leukoencephalopathy with spheroids (HDLS) with known mutations in the colony-stimulating factor 1 receptor gene (CSF1R) onExpand
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Temporal Speech Characteristics of Individuals with Multiple Sclerosis and Ataxic Dysarthria: ‘Scanning Speech’ Revisited
‘Scanning speech’ has been used as a description of a prominent characteristic of the dysarthria of multiple sclerosis (MS) as well as of ataxic dysarthria in general. It is thought to be measurableExpand
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Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS
Objective: To determine if CNS-derived proteins present in the CSF of multiple sclerosis (MS) patients reflect different pathologic processes of MS and if these proteins could be useful as biologicExpand
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Segregation and manifestations of the mtDNA tRNA(Lys) A-->G(8344) mutation of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome.
We have studied the segregation and manifestations of the tRNA(Lys) A-->G(8344) mutation of mtDNA. Three unrelated patients with myoclonus epilepsy and ragged-red fibers (MERRF) syndrome wereExpand
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Incidence of MS during two fifteen‐year periods in the Gothenburg region of Sweden
The average annual incidence of definite and probable MS in Gothenburg was re‐investigated. For 1950–1954, 1955–1959 and 1960–1964 it was 4.2, 4.2 and 4.3/100,000/year. For the five‐year periodsExpand
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