Thymoquinone protects against carbon tetrachloride hetatotoxicity in mice via an antioxidant mechanism
- M. Nagi, K. Alam, O. Badary, O. Al‐Shabanah, H. Al-Sawaf, A. Al-Bekairi
- Biology, ChemistryBiochemistry and molecular biology international
- 1 January 1999
Oral administration of TQ in a single dose resulted in significant (p<0.001) protection against the hepatotoxic effects of CCl4.
Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling
- M. Sayed-Ahmed, A. Aleisa, M. Nagi
- Biology, MedicineOxidative Medicine and Cellular Longevity
- 1 July 2010
TQ supplementation prevents the development of DENA-induced initiation of liver cancer by decreasing oxidative stress and preserving both the activity and mRNA expression of antioxidant enzymes.
Protective effect of aminoguanidine against nephrotoxicity induced by cisplatin in normal rats.
- M. Mansour, A. Mostafa, M. Nagi, M. Khattab, O. Al‐Shabanah
- Biology, MedicineComparative biochemistry and physiology…
- 1 June 2002
Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone.
- M. Mansour, O. Ginawi, T. El-hadiyah, A. El‐Khatib, O. Al‐Shabanah, H. Al-Sawaf
- Biology, ChemistryResearch Communications in Molecular Pathology…
- 2001
The results of the present study indicate that TQ (12.5 mg/Kg, i.p.) may play an important role as antioxidant and may efficiently act as a protective agent against chemically-induced hepatic damage.
Effect of oral administration of arabic gum on cisplatin‐induced nephrotoxicity in rats
- A. Al-Majed, A. Abd-Allah, A. Al-rikabi, O. Al‐Shabanah, A. Mostafa
- BiologyJournal of biochemical and molecular toxicology
- 1 June 2003
The findings suggest that lipid peroxidation is not the main cause of CP‐induced nephrotoxicity but it is rather more dependent on other factors such as platinum disposition in renal interstitial tubules.
Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity.
- O. Badary, M. Nagi, O. Al‐Shabanah, H. Al-Sawaf, M. Al-Sohaibani, A. Al-Bekairi
- Biology, ChemistryCanadian Journal of Physiology and Pharmacology
- 1 December 1997
TQ-induced amelioration of cisplatin nephrotoxicity was evident by significant reductions in serum urea and creatinine and significant improvement in polyuria, kidney weight, and Creatinine clearance, and the current study suggests that TQ may improve the therapeutic index of cisPlatin.
Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats.
- A. Al-Majed, A. Mostafa, A. Al-rikabi, O. Al‐Shabanah
- Medicine, BiologyPharmacological Research
- 1 November 2002
Acute and subchronic toxicity of thymoquinone in mice
- O. Badary, O. Al‐Shabanah, M. Nagi, A. Al-Bekairi, M. Elmazar
- Chemistry
- 1 June 1998
The effects of acute and subchronic administration of thymoquinone (TQ), the main constituent of the volatile oil of the black seeds Nigella sativa, with significant cytoprotective properties, were…
Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity.
- O. Al‐Shabanah, O. Badary, M. Nagi, N. Al-Gharably, A. Al-rikabi, A. Al-Bekairi
- Biology, ChemistryJournal of experimental & clinical cancer…
- 1 June 1998
TQ is supported as a potentially selective cytoprotective agent, which may ameliorate cardiotoxicity without decreasing DOX antitumor activity, and in in vivo study on mouse Ehrlich ascites carcinoma tumor, it could be shown that TQ does not interfere with the antitumors activity of DOX.
Effects of L-carnitine and ginkgo biloba extract (EG b 761) in experimental bleomycin-induced lung fibrosis.
- M. Daba, A. Abdel-Aziz, A. Moustafa, A. Al-Majed, O. Al‐Shabanah, H. El-kashef
- Medicine, BiologyPharmacological Research
- 1 June 2002
The results of the present study indicate the beneficial effects of EGb 761 and L-carnitine against lung toxicity induced by BLM treatment, and shows the advantageous use of EGB 761 as a protective agent in BLM-induced lung fibrosis under the experimental circumstances.
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