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Association analysis of GSTT1, GSTM1 genotype polymorphisms and serum total GST activity with ischemic stroke risk
It is shown that GSTT1 and GSTM1 null genotypes, together with hypertension, may play a significant role in the pathogenesis of ischemic stroke. Expand
Genotype and allele frequencies of polymorphic CYP2E1 in the Turkish population
The genotype distributions of CYP2E1*5B and *6 in Turkish population were similar to those in other Caucasian populations, while differed significantly from East Asian populations. Expand
Significance of Genetic Polymorphisms at Multiple Loci of CYP2E1 in the Risk of Development of Childhood Acute Lymphoblastic Leukemia
Investigation of the possible association of CYP2E1*5B, *6 and *7B alleles, alone or in combination, with the risk of incidence of childhood ALL in a Turkish population found individuals carrying combinations of CYE1-5B-6-B variants together are likely associated with therisk of developing childhood ALL. Expand
Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischemic stroke.
This first report evaluating paraoxonase and arylesterase activities and PON1 activity ratio as risk factors for ischemic stroke identified PON2 activity ratio, Pon1 192RR genotype and P ON1 status as important risk factors. Expand
Characterization and modulation by drugs of sheep liver microsomal flavin monooxygenase activity
Sheep liver microsomal FMO‐catalysed methimazole oxidation was inhibited by imipramine and chlorpromazine when these drugs were used at high concentrations and FMO activity was found to increase with the addition of detergents to the reaction medium. Expand
Epilobium hirsutum alters xenobiotic metabolizing CYP1A1, CYP2E1, NQO1 and GPx activities, mRNA and protein levels in rats
The current data suggest that the metabolism of xenobiotics, including drugs, may be altered due to changes in the expression and activity of these proteins by EH. Expand
Solubilization and partial purification of two forms of cytochrome P-450 from trout liver microsomes.
Liver microsomal cytochrome P-450 content, NADPH-cytochrome c reductase, aniline 4-hydroxylase and ethylmorphine N-demethylase activities of rainbow trout, Salmo gairdneri, were found to be 0.16 (n =Expand
A Comparative Study for the Evaluation of Two Doses of Ellagic Acid on Hepatic Drug Metabolizing and Antioxidant Enzymes in the Rat
The results indicate that EA exerts a dose-dependent impact on the metabolism of chemical carcinogens and drugs by affecting the enzymes involved in xenobiotics activation/detoxification and antioxidant pathways. Expand
Analysis of paraoxonase 1 (PON1) genetic polymorphisms and activities as risk factors for ischemic stroke in Turkish population
This study aimed to determine the importance of −107T/C, 192Q/R and 55L/M polymorphisms of Pon1 gene and three PON1 activities (diazox onase, paraoxonase, arylesterase) as risk factors for ischemic stroke. Expand
Apolipoprotein A5 polymorphisms in Turkish population: association with serum lipid profile and risk of ischemic stroke
It is demonstrated that carrying rare alleles of APOA5 S19W, −1131T>C and G185C alone do not constitute a risk for ischemic stroke in the studied Turkish subjects. Expand