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CD28-mediated co-stimulation: a quantitative support for TCR signalling
TLDR
Recent genetic, biochemical and biophysical data indicate that a modified view of the molecular mechanism by which ligation of CD28 amplifies TCR-mediated T-cell activation should be revised. Expand
Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction
TLDR
It is shown that catalytically active Lck was present in unstimulated naive T cells and thymocytes and was readily detectable in these cells in lymphoid organs and suggest a dynamic regulation of Lck activity that can be promptly utilized to initiate T cell activation and have implications for signaling by other immune receptors. Expand
Tailoring T-cell receptor signals by proximal negative feedback mechanisms
TLDR
In vitro and in vivo data suggest that negative feedback mechanisms that are rapidly induced by TCR engagement and that have key roles in the regulation of signal triggering and propagation are important in determining ligand discrimination by the TCR and in regulating signal output in response to antigen. Expand
A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of D-glucose and choline
TLDR
These vesicles prove to be excellently suited for transport studies, as suggested by the measurements of D-glucose transport, and the mode of choline transport across the brush border membrane was investigated. Expand
p95vav associates with tyrosine-phosphorylated SLP-76 in antigen- stimulated T cells
TLDR
This work shows that physiological stimulation of T cell hybridomas with antigen presented by major histocompatibility complex class II molecules leads to a strong tyrosine phosphorylation of p95vav and its association with tyrosinesine- phosphorylated SLP-76, a newly described SH2-containing protein. Expand
An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein
TLDR
Given that T11 is the earliest T-lineage surface glycoprotein to appear in thymic ontogeny and is thus expressed before T3-Ti, the former may be involved in clonal expansion and/or differentiation during early development. Expand
T cell activation and the cytoskeleton.
TLDR
T cell signal transduction is triggered physiologically by antigen in the context of antigen presenting cells (APC) and the formation of stable and prolonged contacts between T cells and APCs is required for effective T cell proliferation and differentiation. Expand
T cell receptor for antigen induces linker for activation of T cell–dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2
TLDR
The findings support the view that Dok-1 and -2 are critical elements of a LAT-dependent negative feedback loop that attenuates early TCR signal and may exert a critical role in shaping the immune response and as gatekeepers for T cell tolerance. Expand
A Method for Large-scale Identification of Protein Arginine Methylation*
TLDR
By extending considerably the number of known arginine methylation sites, the data reveal a novel proline-rich consensus motif and identify for the first time arginin methylation in proteins involved in cytoskeleton rearrangement at the immunological synapse and in endosomal trafficking. Expand
CPFP: a central proteomics facilities pipeline
TLDR
The central proteomics facilities pipeline provides identification, validation, and quantitation of peptides and proteins from LC-MS/MS datasets through an easy to use web interface, reducing the data analysis load on staff, and allowing facility clients to easily access and work with their data. Expand
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