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Biophysical and antisense properties of oligodeoxynucleotides containing 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2'-deoxyadenosines.
The synthesis of 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2'-deoxyadenosines is described. The nucleosides were synthesized, functionalized into the phosphoramidites and incorporated intoExpand
Non-enzymatic transcription of an oligodeoxynucleotide 14 residues long.
The 14-mer oligodeoxynucleotide d(C3GC3GC3GC2) acts as a template to facilitate the cooligomerization of guanosine 5'-phospho-2-methylimidazolide and cytidine 5'-phospho-2-methylimidazolide. TheExpand
Synthesis of propane-2,3-diol combinatorial monomers
Abstract Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol gives heteroarylpropane-2,3-diols which are functionalized to the 3-O-dimethoxytrityl-2-O-phosphoramidites. AExpand
Rapid communication: Inhibition of adenosine deaminase by azapurine ribonucleosides
We have synthesized several 8-azapurine nucleosides as inhibitors of adenosine deaminase. The presence of a nitrogen on the imidazole ring decreased the Ki value for nebularine by 100-fold but didExpand
Deconvolution of combinatorial libraries for drug discovery: experimental comparison of pooling strategies.
An experimental evaluation of several different pooling strategies for combinatorial libraries was conducted using a library of 810 compounds and an enzyme inhibition assay (phospholipase A2). TheExpand
The coherence of synthetic telomeres.
The chromosomal telomeres of Oxytricha were synthesized and their ability to cohere examined on non-denaturing acrylamide gels containing the stabilizing cation K+. At least 5 different mobilityExpand
3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing
Further structure-activity relationship studies of a series of substituted uracils at the 1, 3, and 5 positions resulted in the discovery of several potent antagonists of the humanExpand
Drug leads from combinatorial phosphodiester libraries.
Template-directed oligonucleotide ligation on hydroxylapatite
Bernal1, and subsequently other authors2, have suggested that the prebiotic synthesis of the precursors of biopolymers could have occurred on a solid surface such as that provided by clay or someExpand
Synthesis of N-substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries
Abstract A series of N-substituted DMT-hydroxymethylpyrrolidinol phosphoramidites has been prepared from trans-4-hydroxyproline. These can be coupled in high yield and purity using automatedExpand