O. Yu. Printseva

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Ca2+-activated K+ ionic currents in the membrane of cultured smooth muscle cells isolated from foetal and adult human aorta were studied using whole cell and single-channel patch-clamp techniques. Whole cell currents in adult smooth muscle cells were 3–8 times larger than in foetal cells of similar sizes. The elementary conductance and ionic selectivity of(More)
The method now developed not only enables demyelinization to be detected and the state of the various cells in nerve tissue to be studied in the same preparations, but it also enables the time spent on preparing the material for histological investigation to be greatly reduced (for sealing in celloidin to one month, for embedding in paraffin wax to 1.5(More)
A significant increase (up to 20% from about 10% in normals) in the number of smooth muscle cells (SMC) with tetraploid DNA content was found in the media and intima of human hypertensive aorta. A similar process was detected during normal human vessel aging. It was found that SMC from normal human aorta and normotensive rat aorta, which were able to(More)
Tissue culture, in which cells undergo analogous changes, is a convenient model with which to study these phenomena and the factors influencing them. However, it has been shown that the dynamics of these changes depends on the conditions and times of culture [9]. Accordingly it is important to obtain long-term cultures of smooth-muscle cells with definite(More)
Monoclonal antibodies to a surface antigen of the modulated smooth muscle cells originally isolated from the rat aorta media were conjugated with ricin A-chain via an oxidized dextran bridge. The interaction of cultured cells with the conjugates obtained and with control substances was monitored following incorporation of14C-leucine radioactivity. It was(More)
The problem of thickenings in the intima of~large blood vessels has been studied experimentally by many workers. Most of them have concluded that thickening of the intima, especially in atherosclerosis, is formed on account of smooth-muscle cells (SMC) which migrate into it from the media [7, 8, i0, 12-14]. These investigations have been conducted mainly by(More)
Artery specimens obtained during surgical manipulations from 11 patients suffering from nonspecific aortoarteritis (NAA) were studied immunohistochemically for T4, T8-positive lymphocytes, LFA-1-positive lymphocytes, basal membrane (BM) proteins: laminin and type IV collagen. T8-positive and LFA-1-positive cells were shown to be predominant in the sites of(More)
The localization of angiotensin-converting enzyme (ACE) in human tissues has been studied by the PAP-method with the use of monoclonal antibody 9B9 against human lung ACE. The enzyme was detected on the surface of endothelial cells in lung, myocardium, liver, intestine and testis as well as in the epithelial cells of the kidney proximal tubules and(More)
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