O. V. Osipov

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Acute poisoning with alcohols and cholinotropic preparations carboxyphosphamide and atropine (0.8 LD50) was modeled on male outbred mice weighing 18-24 g. The decrease in activity of natural killer cells was most pronounced after injection of atropine, but insignificant after treatment with ethanol. The inhibitory effect of ethylene glycol, methanol, and(More)
In vitro experiments on splenocytes from noninbred mice showed that ethylene glycol, methanol, and ethanol dose-dependently suppressed functional activity of T and B cells. These compounds in equimolar concentrations (10, 100, and 500 mM) produced similar effects, hence their immunotoxicity is determined by their metabolites. The suppressive effects of(More)
The results of experiments on male mongrel mice showed that a three-day treatment with T-activin in a dose of 2.5 micrograms/kg restored the activity of natural killer cells reduced by acute poisoning (1 LD50) with ethylene glycol (EG), methanol (MeOH), and ethanol (EtOH). In a dose of 5 micrograms/kg, T-activin produced the same action in the test animals(More)
The M680I and M694V mutations located in the B30.2 pyrin domain are responsible for the manifestation of the most common forms of Familial Mediterranean fever. It is well known that a malfunction of the pyrin-caspase-1 complex is the main cause of inflammation in FMF. The purpose of this study was to identify possible changes in the tertiary structure of(More)
The M680I and M694V mutations located in the B30.2 pyrin domain are responsible for the manifestation of the most common forms of Familial Mediterranean fever. It is well known that a malfunction of the pyrin–caspase-1 complex is the main cause of inflammation in FMF. The purpose of this study was to identify possible changes in the tertiary structure of(More)
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