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We present the computer tool FUNSITE for description and analysis of regulatory sequences of eukaryotic genomes. The tool consists of the following main parts: 1) An integrated database for genomic regulatory sequences. The integrated database was designed on the basis of the databases TRANSFAC (Wingender 1994) and TRRD (Kel et al. 1995) that are currently(More)
GeneExpress system has been designed to integrate description, analysis, and recognition of eukaryotic regulatory sequences. The system includes 5 basic units: (1) GeneNet contains an object-oriented database for accumulation of data on gene networks and signal transduction pathways and a Java-based viewer that allows an exploration and visualization of the(More)
Cellular functions and activities are governed by complex signaling and regulatory networks. Diseases arise from abnormal behavior in these networks. Thus the design of targeted therapies from a systems biology approach, aims to identify which molecules to intervene in these networks , to repress a pathological behavior while minimizing side-effects.(More)
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