Establishment of long-range fiber tracts by neocortical projection neurons is fundamental for higher brain functions. The molecular control of axon tract formation, however, is still poorly understood. Here, we have identified basic helix-loop-helix (bHLH) transcription factors Neurod2 and Neurod6 as key regulators of fasciculation and targeted axogenesis… (More)
Primary central nervous system lymphoma (PCNSL) is a highly aggressive Non-Hodgkin lymphoma (NHL) with rising incidence over the past 30 years in immunocompetent patients. Although outcomes have improved, PCNSL is still associated with inferior prognosis compared to systemic NHL. Many questions regarding the optimal therapeutic approach remain unanswered.… (More)
We review the involvement of macro- and microelements in neuroontogeny, including transpla-cental transition, distribution in the brains of fetuses and neonates, its role in the maturation of the central nervous system, and neuronal functions in the norm, during abnormal pregnancy, and under the influences of pathological factors.