O. V. Batishchev

Learn More
BACKGROUND H5N1 influenza vaccines, including live intranasal, appear to be relatively less immunogenic compared to seasonal analogs. The main influenza virus surface glycoprotein hemagglutinin (HA) of highly pathogenic avian influenza viruses (HPAIV) was shown to be more susceptible to acidic pH treatment than that of human or low pathogenic avian(More)
Influenza A virus matrix protein M1 is one of the most important and abundant proteins in the virus particles broadly involved in essential processes of the viral life cycle. The absence of high-resolution data on the full-length M1 makes the structural investigation of the intact protein particularly important. We employed synchrotron small-angle X-ray(More)
The process of electroporation of bilayer lipid membranes made of diphytanoylphosphatidylcholine (DPhPC) has been studied. DPhPC combines a polar part typical for lipids of eukaryotic cells and branched isoprenoid chains forming the hydrophobic “tails” of archaea lipids. From the experimental dependence of the average lifetime on the magnitude of the(More)
Theoretical model of structure of through pore in lipid bilayer is developed. We assumed that hydrophobic void can appear between monolayers of the membrane. The void is supposed to be filled by organic solvent or low-polarity impurities, which are usually present in artificial and cell membranes. The pore edge was divided to three regions: two monolayer(More)
We consider the process of fusion of lipid membranes from the stage of stalk with minimal radius to the stage of fusion pore. We assume that stalk directly developed into the fusion pore, omitting the stage of hemifusion diaphragm. Energy of intermediate stages is calculated on the basis of the classical elasticity theory of liquid crystals adapted for(More)
The heating and evolution of ionized single cluster in a strong laser field is studied with molecular dynamics simulation. The electron temperature increase and particle expelling from evolution of deuterium and iron clusters are discussed. It is shown that the optimal regime for effective electron heating corresponds to laser field comparable to the(More)
  • 1