Learn More
Certain forms of the heavy metals arsenic and chromium are considered human carcinogens, although they are believed to act through very different mechanisms. Chromium(VI) is believed to act as a classic and mutagenic agent, and DNA/chromatin appears to be the principal target for its effects. In contrast, arsenic(III) is considered nongenotoxic, but is able(More)
Previously, we have described the establishment of a subpopulation of cancer stem cells from the human colorectal carcinoma cell line MIP101. These cells exhibit enhanced clonogenic and tumorigenic capacities. Depletion of the stem compartment in the cancer cell population blocks its tumorigenicity. The present work is dedicated to a comparison of the(More)
The present work is an attempt to compare cancer cells of the same origin but differing in the expression of CEA protein, a clinical marker of metastatic carcinomas. CEA, presumably, is one of the key factors in metastatic activity. We investigated the morphology of cell colonies in vitro, the expression pattern of epithelial markers, and the ability of(More)
  • 1