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Massive air embolisation (persufflation) of four machine-perfused human kidneys occurred during preservation. This lasted for 60-120 min and caused increasing perfusion resistance. Pressure and flow returned to normal within 2 h after reperfusion. All kidneys showed immediate function after transplantation. Experiments with dog kidneys revealed closure of(More)
In kidneys perfused hypothermically for 48 hr, both major intracellular pools of CoA (present in cytosol and mitochondria) decreased when solutions with intracellular or extracellular electrolyte composition without CoA precursors were used. The presence of substrates such as glucose or caprylic acid in the perfusate did not counteract the depletion of CoA.(More)
Forty-eight-hour preservation of dog kidneys utilizing continuous hypothermic perfusion was carried out in two groups of dogs. In the first group an albumin electrolyte solution with a high content of free fatty acids was used as perfusate. In the second group the perfusate contained the same components as the first solution except that the fatty acids had(More)
Dog kidneys were preserved for 48 hours by hypothermic perfusion with either a glucose-rich or a glucose-free albumin perfusate. After reimplantation and contralateral nephrectomy renal function was assessed by serum creatinine determinations. The kidneys showed normal function and no difference between the two groups was found. The results suggest that(More)
Perfusion of isolated dog kidneys was performed at 8--12 degrees C using an albumin solution containing caprylic acid (about 6 mmol/l) and long-chain fatty acids (about 0.5 mmol/l). During 48 h the amounts of caprylic acid in the perfusate fell by about 3 mmol, whereas long-chain FFA increased by 0.2--0.3 mmol and small amounts of arachidonic acid appeared.(More)
Dog kidneys were perfused for 48 h at 8-10 degrees C with two different perfusion fluids: one fluid rich in glucose, and another in which mannitol was a substitute for glucose. Immediately after reimplantation of the perfused kidneys, contralateral nephrectomy was performed. Kidney function, estimated by serum creatinine, was the same in both groups of(More)
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