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Oncoretroviral vectors have been successfully used in gene therapy trials, yet low transduction rates and loss of transgene expression are still major obstacles for their application. To overcome these problems we modified the widely used Moloney murine leukemia virus-derived retroviral vector pMX by replacing the 3′LTR with the spleen focus-forming virus(More)
During the past decades the components involved in cellular signal transduction from membrane receptors to gene activation in the nucleus have been studied in detail. Based on the qualitative biochemical knowledge, signalling pathways are drawn as static graphical schemes. However, the dynamics and control of information processing through signalling(More)
The small cytokine-inducible SH2 domain-containing protein (CIS) has been implicated in the negative regulation of signaling through cytokine receptors. CIS reduces growth of erythropoietin receptor (EpoR)-dependent cell lines, but its role in proliferation, differentiation, and survival of erythroid progenitor cells has not been resolved. To dissect the(More)
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