O. P. Sakharova

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The tetanus toxin (TT) action on crude glutamic acid decarboxylase (GAD) preparation and GAD activity of synaptosomes were studied. TT was not found to affect GAD, but the GAD activity of synaptosomes isolated from the rat brain cortex increased by 46% after 15 min of incubation in the presence of a dose of 0.1 DLM TT. In some experiments, the GAD activity(More)
Activity of Na, K -ATPase, acetylcholinesterase (AChE) and glutamic acid decarboxylase (GAD) in the fractions of the rat brain and spinal cord tissue were studied in rats during a single electroshock (ES) and 5 and 30 minutes after it. GAD activity of the synaptosome fraction was shown to decrease insignificantly, but activity of AChE, Na, K -ATPase and(More)
(1980). 3. V. D. Paponov, P. S. Gromov, and D. M. Spitkovskii, Byull. Eksp. Biol. Med., No. 6, 672 (1981). 4. F. Caron and J. O. Thomas, J. Mol. Biol., 14__~6, 513 (1981). 5. F. Grellet, M. Delseney, and Y. Guitton, Nature, 267, 724 (1977). 6. R. D. Kornberg, Sciences, 184, 865 (1974). 7. U. K. Lae,,-li, Nature, 227, 680 (1970). 8. J. D. McGhee and G.(More)
Activity of Na,K-ATPase, acetylcholinesterase (AChE), and glutamate decarboxylase (GDC) was investigated in fractions of the rat brain and spinal cord during and 5 and 30 min after a single electric shock. GDC activity of the brain “synaptosomes” was reduced but not significantly, whereas activity of AChE, Na,K-ATPase and, probably, proteolytic enzymes was(More)
The social and clinical background of 1,043 tuberculosis patients newly recognized as disabled was studied. A complex study of the interrelation between tuberculosis-induced disability and medical and social factors was undertaken. Ineffective treatment proved to be the leading cause of disability, associating with untimely detection of the disease in 19.4%(More)
The isoelectric points (PIs) of proteins present in the “Diaferm-3” antitetanus serum, a mixture of partially purified [F'ab]2-fragments of native molecules of antitetanus immunoglobulins, their antitoxic activity, and their immunochemical properties were investigated by isoelectric focusing in a pH gradient of ampholines. The PI values and electrophoretic(More)
As shown by the method of electrophoresis on polyacrylamide gel, the number of proteins with low electrophoretic mobility proved to be increased in the triton extract fractions of synaptic structures isolated from spinal cord of rats with local tetanus; no changes in the protein spectrum were revealed in the dodecyl-sulphate extract. In vitro tetanus toxin(More)