O N Titova

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Surgical treatment (tooth removal) of 63 patients with malignant maxillofacial tumors was carried out before, during and 6 months after radiotherapy. A total of 113 teeth were removed because of chronic foci of infection in the periapical tissues. The results of dynamic observations indicate that the risk of complications in this patients population is not(More)
A method for experimental reproduction of stages of chronic obstructive pulmonary disease formation (from acute inflammation to bronchopulmonary tissue restructuring characteristic of this disease) is presented. Lung injury and inflammation were induced by nitrogen dioxide. Hyperplasia and hypersecretion of goblet cells, squamous cell metaplasia of the(More)
Chronic obstructive pulmonary disease (COPD) is among the leading causes of morbidity and mortality worldwide. Glucocorticoids are currently the most applicable anti-inflammatory treatment for COPD. However, a subset of COPD subjects is relatively insensitive to this treatment. Fenspiride, a non-corticosteroid anti-inflammatory drug, has been described to(More)
BACKGROUND Pathogenesis of chronic obstructive lung disease (COPD) includes primary inflammatory events, multiple vascular reactions, remodeling of bronchial and vascular walls. OBJECTIVE The aim of present single-center study was to assess relations between angiotensin-converting enzyme (ACE) gene and prevalence of clinical symptoms characteristic to(More)
The role of mast cells in contractile bronchial smooth muscle activity has been evaluated in a model of chronic obstructive pulmonary disease induced in rats that were intermittently exposed to nitrogen dioxide (NO2) for 60 days. Starting from the 31st day, one group of rats inhaled sodium cromoglycate before exposure to NO2 to stabilize mast cell(More)
Diagnostic lumbar punctures were performed in 60 patients suffering from different organic diseases of the central and peripheral nervous systems. Out of 60 persons, 30 developed postpuncture headache. Comparison of the personality traits in patients with and without postpuncture headache, made according to the MMPI technique, has shown significant(More)
This open prospective randomized parallel-group comparative study included 43 patients with moderate or severe chronic obstructive pulmonary disease (COPD). The patients of active working age were referred to the disability groups II-III based on the average forced expiratory volume in 1 second (1.70+/0.43 1 or 49.1+/-10.7% the normal value) and received an(More)
In the model of chronic obstructive pulmonary disease (COPD), produced in rats by 60-day exposure to nitrogen dioxide, the effect of drugs with endotelioprotector properties (sulodexide and rosuvastatin) on the functional state of small pulmonary arteries and bronchi was studied. We evaluated the contractile activity of smooth muscle strips of the bronchi(More)
Clinical and cardiorespiratory findings in patients with chronic obstructive pulmonary disease (COPD) stage I and IIA and the results of exercise tolerance tests in patients with mild and moderate bronchial asthma (BA) at a remission stage were studied for effects of positive oscillatory expiratory pressure created in respiration through flatter on exercise(More)