O. N. Podmareva

  • Citations Per Year
Learn More
441 The action of cAMP on intracellular processes is mediated by protein kinase A (PK-A), cAMP-sensitive ionic channels of plasma membrane, and Epac proteins (exchange proteins activated by cyclic AMP), which activate the replacement of GTP by GDP in the lowmolecular-weight G-proteins Rap1 and Rap2 [1]. There are two types of Epac proteins, Epac1 and Epac2,(More)
The uterus of immature mammalian females has a spontaneous contractile activity [1, 2], which is regulated by the hypogastric and pelvic nerves innervating the uterus and containing cholinergic and adrenergic nerve fibers [3]. The presence of this type of fibers is corroborated by morphological data [3–5] and the results of physiological studies. For(More)
Proteinases (thrombin, trypsin, etc.) are known to degrade extracellular proteins and can also serve as signalling molecules. The effects of these enzymes are mediated by specific cell-membrane receptors referred to as proteinase-activated receptors (PARs). The latter are bound to G-proteins and are activated after cleavage of the extracellular portion of(More)
Serotonin, acetylcholine and noradrenaline neither initiated nor indicated the uterus contractility in immature or pregnant mice; they, however, regulated the uterine motility in respect to the neurotransmitters concentration and the hormonal status of females. Inactivation of the beta-receptors in longitudinal muscle fibres prevented the drop in the(More)