O . I . Rudko

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The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors. In the blood of healthy donors, RHOA and CKAP2 gene expression was not detected, and low SEMA3B gene expression was observed. Significant elevation of expression of all the three genes was shown in the case of acute(More)
Panic disorder is a common, socially important human neurological disease. It is known that this disease has a strong genetic basis. Many laboratories investigate candidate genes involved in the control of pathological anxiety. This review summarizes the results of these studies and testify that the development of a panic disorder is associated with the(More)
Long-term depressive behavior was modeled via immunization of white rats with isatin (an endogenous MAO inhibitor) covalently bound to a carrier antigen. The immunization of rats against isatin and several exogenous MAO inhibitors (pargyline and deprenyl) resulted in long-term (2 months) depressive-like behavior with elements of anxiety and an increased(More)
Long-term depressive behavior was modeled via immunization of white rats with isatin (an endogenous MAO inhibitor) covalently bound to a carrier antigen. The immunization of rats against isatin and several exogenous MAO inhibitors (pargyline and deprenyl) resulted in long-term (2 months) depressive-like behavior with elements of anxiety and an increased(More)
This article presents the study of the effects of 5-hydroxytryptamine-modulin—a poorly studied endogenous peptide (Leu-Ser-Ala-Leu)—which specifically interacts with 5-HT1B-auto- and heteroreceptors. Data obtained in the experiments on rats suggest prolonged anxiolytic and antidepressive effect of intranasal 5-HT-modulin administration and give evidence to(More)
BACKGROUND Migraine is a multifactorial socially significant disease affecting the peripheral and central nervous system. The diagnosis of "migraine" is still the only clinical, and additional methods of inspection are only required to avoid secondary headaches if certain "signs of danger". Accordingly, the search for biomarkers of migraine, confirming the(More)
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