O. I. Kostyleva

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Serum levels of insulin-like growth factors (IGF-1 and IGF-2), IGF-binding proteins (IGFBP-1, IGFBP-2, and IGFBP-3) and vascular endothelial growth factor (VEGF) were measured by standard ELISA technique in 95 primary colorectal cancer patients and 48 healthy individuals. Significant increase in serum levels of IGF-1, IGFBP-2, and VEGF and decrease in(More)
The levels of EGFR and its ligands have been assayed in tumor and adjacent lung tissues in NSCLC patients. Both EGFR and EGF-like peptides were found in tumor more frequently than in unaltered tissue. It was shown (Kaplan-Meyer) that simultaneous expression of EGFR and its ligands in tumor and adjacent lung tissues was associated with lower overall and(More)
The radioligand technique was used to study the amount of epidermal growth factor receptors (EGFR) in malignant and benign tumors in 32 children aged 8 months to 17 years. The membranous fraction of 11 of the 32 tumors studied showed EGFR equal to 10.1 to 1327 fmol/mg (163.0 +/- 117.5 fmol/mg, median 38.0 fmol/mg). The greatest amount of EGFR was found in(More)
The content of receptors for the epidermal growth factor and estrogens is studied in primary human bone tumors: osteogenic sarcoma, chondrosarcoma, malignant fibrous histiocytoma, and giant cell tumor. In all of these tumors, radioligand analysis reveals receptors for epidermal growth factor in the membrane fraction and receptors for estrogens in the(More)
The relative binding affinity of nonsteroidal antiestrogen tamoxifen to the cytosol estradiol receptors of hyperplastic and unaltered myometria in patients with leiomyoma has been studied. Relative binding affinity of tamoxifen in tumor tissues exceeded one in normal myometrium.
  • E. N. Kareva, O. I. Kostyleva
  • 2004
Uterine myoma is an estradiol-dependent hyperplastic process developing on a background of chronic hyperestrogenia in women of reproductive age. The treatment of uterine myoma of interstitial and subperitoneal localization includes hormonal preparations with androgenic activity, estrogen-gestagens, and synthetic progestins, in order to obtain an(More)
Estradiol and progesterone cytosol receptors, tamoxifen relative binding capacity in endometrial tissue samples, serum estradiol and progesterone levels were studied in 60 postmenopausal patients with hyperplastic processes in the endometrium. Estradiol and progesterone receptor levels were increased in glandular cystic polyp tissue, in atypical(More)
The content of MMP-8 and MMP-9 in oral fluid of 145 patients (95 women and 50 men, 18-52 years) was measured by enzyme immunoassay. We examined 63 subjects with the intact periodontium and 82 patients with chronic generalized periodontitis (25 patients with mild disease, 45 patients with moderate disease, and 12 patients with severe disease). All patients(More)