O. H. Kehrhahn

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The pharmacokinetics of propafenone (Rytmonorm) was studied in 19 healthy volunteers. Propafenone was given intravenously (commercial ampoules of 70 mg) and orally in different doses (150, 300, 450 mg) and forms (solution, commercial film tablets). The results show a dose dependence of bioavailability and maximum plasma concentrations after oral application(More)
Seven normal male volunteers received an injection of 208 mg theophylline-anhydride (Solosin) each for 4 min, and a 225-mg single oral dose (Afonilum) on separate occasions. The concentration of unchanged theophylline was analyzed over a 24-h period in plasma and over a 48-h period in urine, after both dosage forms. A two-compartment model was required to(More)
The relationships between the linear free energy related Hansch model and the mathematical models of Free-Wilson and Bocek-Kopecký are reviewed and discuss. Some examples are given to illustrate the theoretically derived relationships and to demonstrate scope and limitations of each mathematical model. The modified Free-Wilson approach is shown to be(More)
The bilinear model, log 1/C = a log P--b log (betaP + 1) + c, is a new model for the qunatitative description of non-linear relationships between hydrophobic character and biological activity. In contrast to the parabolic Hansch model the bilinear model considers the particular effect that a linear relationship exists between lipophilicity and biological(More)
Real lens diameter and real lens volume cannot be measured by Scheimpflug photography, but the apparent lens radii and the lens thickness (anterior and posterior) can. Some stereometric equations allow us to calculate lens volume and lens diameter. Equations for the adaptation of the data points to nonlinear curves are given. There are no linear but sigmoid(More)
Seven normal male volunteers each received an injection of 208 mg theophylline anhydride for 4 min, and a 185-mg single oral dose theophylline anhydride (Broncho-Afonilum) on separate occasions. The concentrations of unchanged theophylline was analyzed over a 24-h period in plasma and a 48-h period in urine after both dosage forms. A 2-compartment model was(More)
Blood pressure, ECG and plasma concentration were determined for up to 12h following single i.v. (10 mg) and oral (20 mg) doses of amezinium (Regulton®) in 8 healthy, male volunteers. The i.v. and oral doses were almost equi-active in significantly increasing systolic blood pressure (SBP) by 14.5 and 15.6 mmHg, respectively. The maximum SBP after the i.v.(More)
The absolute bioavailability and pharmacokinetics of 4-amino-6-methoxy-1-phenyl-pyridazinium methyl sulfate (amesiniummetilsulfate, LU 1631, Regulton), in the following briefly called amezinium, were examined following i.v. injection (10 mg) and single p.o. doses administered to eight healthy male volunteers. After i.v. injection plasma levels of amezinium(More)
The Fujita-Ban model and the classical Free-Wilson model are shown to be linearly related: the de novo group contributions obtained by one model are linear transformations of those obtained by the other model. An example is given to illustrate this linear dependence. The Fujita-Ban model is characterized by a number of advantages as compared with the(More)