O. G. Khaziakhmatova

Learn More
The alternative splicing of the Ptprc gene is a key event in memory T-cell differentiation. This gene encodes a transmembrane tyrosine phosphatase CD45. One of the potential mechanisms of alternative splicing regulation is based on the antagonistic effects of a U2AF26 auxiliary splicing factor and Gfi1 transcription factor. These two proteins regulate(More)
The role of human pregnancy-specific β1-glycoprotein (PSG) in the regulation of expression of the transcription factor FOXP3 was studied. It is found that, under conditions of directed induction of phenotypic changes in CD4+ lymphocytes to regulatory T cells (Treg), PSG at high concentrations (10 and 100 μg/mL) increased FOXP3 expression. The evaluation of(More)
Opposite effects of common γ-chain cytokines (IL-2, IL-7, and IL-15) on the expression of Gfi1 and U2af1l4 genes regulating alternative splicing of Ptprc gene in T cells at different stages of differentiation were demonstrated in vitro. Generally, produced a dose-dependent activating effect on T cells, while to the effects of rIL-7 and rIL-15 on T cells at(More)
Glucocorticoids are anti-inflammatory and immunosuppressive agents with pleiotropic effects on the growth, differentiation, and functional activity of T lymphocytes. The comprehensive assessment of the influence of dexamethasone on the functional activity of T cells with different grades of differentiation was performed under experimental in vitro(More)
  • 1