O. A. Golovleva

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The distribution in the organism of radioactivity after intratracheal administration of labelled heparin and its quarterly ammonium salt oligomer-25 conidine was studied. Within 25 hours the preservation of a high level of radioactivity in plasma, its decrease in other investigated organs and the accumulation in mast cells of the peritoneal cavity were(More)
The creation of long-lasting, moderate hypocoagulation is an essential therapeutic component in the treatment of various diseases whose course is complicated by the DBC syndrome [1, 4]. However, this effect is difficult to achieve by parenteral injection of heparin because of the rapid elimination of the substance from the blood stream and the risk of(More)
Ionophore activity of ionenes, like that of polymyxins, is shown to be potentiated by long-chain antiions. Rapid stoichiometric anion equilibration in isoosmotic buffered sugar medium revealed that the amplitude of Cl−/OH− exchange in erythrocytes induced by an ionene-detergent complex gradually drops with the decrease of both the charge density and the(More)
The comparative study of intratracheal and intravenous effect of administration of heparin on blood clotting and mast cell population condition was carried out in experiments. Unlike intravenous bolus injection of heparin, which induced fast short-time inactivation of all enzyme clotting factors, a single intratracheal injection inactivated "internal" rout(More)
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