Nyuko Kikuchi

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Dipeptidyl peptidase-4 (DPP-4) inhibitor is a new class of anti-diabetic drug which exerts its glucose-lowering action by suppressing the degradation of a gut incretin hormone glucagon-like peptide-1 (GLP-1). To elucidate whether treatment with stronger DPP-4 inhibitor on top of angiotensin II type 1 receptor blocker (ARB) provides greater renal protective(More)
C57BL/10SnJ mice were run to exhaustion on a treadmill at a 20 degrees incline, uphill or downhill. Contractility, morphology, and histology were evaluated in the soleus and extensor digitorum longus (EDL) muscles at days 0, 3, and 7 postexercise. Serum creatine kinase was elevated immediately postexercise (681% increase downhill and 225% increase uphill).(More)
We investigated the use of intravenously injected fluorescent dextran molecules (FDx) as a histological marker of sarcolemmal injury. Using fluorescent microscopy, uptake of FDx (average MW 10 kD) was assessed in sections of quadriceps muscles from three models: 1) normal (C57BL/10SnJ) mice, 2) normal mice run downhill (0, 3, and 7 days post exercise), and(More)
Autonomic neuropathy is one of the complications of diabetes. Recently, several authors reported that measuring R-R interval variation of ECG is a noninvasive and useful method for testing parasympathetic function. However, there were few reports about sympathetic function in diabetics. In order to evaluate sympathetic function in diabetics quantitatively,(More)
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