Nuwan Niyadurupola

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PURPOSE There is evidence implicating ischemia and excitotoxicity in the pathogenesis of glaucoma. ATP-mediated excitotoxicity via activation of the P2X7 receptor (P2X7R) has been proposed to play a role in retinal ganglion cell (RGC) degeneration in this disease. The aim of this research was to determine whether stimulation of the P2X7R mediated(More)
Pigment dispersion syndrome (PDS) is an interesting condition that can lead to secondary open angle glaucoma. Pigmentary glaucoma is primarily a disease of young people, myopes and men. PDS is characterized by the presence of Krukenberg spindles, iris trans-illumination defects, trabecular meshwork pigmentation and backward bowing of the iris. Posterior(More)
Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotective in models of combined oxygen/glucose(More)
PURPOSE To report a case of Acanthamoeba keratitis that occurred in a daily disposable contact lens wearer. METHOD Case report. RESULTS A 70-year-old gentleman presented to eye casualty with a red left eye with reduced vision and corneal epithelial changes. Acanthamoeba keratitis was not suspected initially as he was a daily disposable contact lens(More)
BACKGROUND To evaluate the effect of phacoemulsification on trabeculectomy function. DESIGN Retrospective case-control study. PARTICIPANTS Forty-eight patients who underwent trabeculectomy surgery and had at least 2 years of follow up. METHODS Patients were classified into two groups: patients who had phacoemulsification subsequent to trabeculectomy(More)
BACKGROUND To determine whether postoperative subconjunctival bevacizumab significantly alters bleb vascularity. DESIGN A randomized, prospective interventional study. PARTICIPANTS Forty-three eyes from 39 patients were recruited, with 21 eyes randomized to subconjunctival injections of 5-fluorouracil, and 22 eyes to combined 5-fluorouracil/bevacizumab.(More)
PURPOSE The aim of our study was to determine whether IOP lowering in glaucomatous and ocular hypertensive (OHT) eyes leads to an improvement in the full-field photopic negative response (PhNR) of the electroretinogram. METHODS A prospective nonrandomized interventional cohort study was conducted. Patients with OHT or glaucomatous optic neuropathy were(More)
AIMS To develop human organotypic retinal cultures (HORCs) to study retinal ganglion cell (RGC) death in response to ischaemic and excitotoxic insults, both known to cause loss of RGCs and proposed as mechanisms involved in glaucomatous retinal neurodegeneration. METHODS Human donor eyes were obtained within 24 h post mortem. The retina was isolated and(More)
The purpose of this study was to present the management of a series of patients referred with infraorbital nerve paraesthesia that developed after insignificant orbital floor fracture without diplopia or exophthalmos, and that did not require initial surgical repair. This is a retrospective interventional case series. The main outcome and measures were(More)