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Multiplex amplification refractory mutation system (MARMS) for the detection of β-globin gene mutations among the transfusion-dependent β-thalassemia Malay patients in Kelantan, Northeast of…
- Sarifah Hanafi, R. Hassan, B. Zilfalil
- Medicine, BiologyAmerican Journal of Blood Research
- 5 September 2014
This method has successfully identified the mutation spectrum in the authors' cohort of transfusion-dependent beta thalassemia patients, and this method is equally effective in screening for mutation among thal Straussmia patients.
Practice of iron chelation therapy for transfusion-dependent thalassemia in Southeast Asia
The scope of iron chelation practices including the types of chelators that are available in Southeast Asia are discussed, and issues relevant to the treatment of transfusion-dependent thalassemic patients in this region are explored.
Genetic polymorphisms of HbE/beta thalassemia related to clinical presentation: implications for clinical diversity
The significant SNPs found in this study were mostly related to thalassemia complications such as rs7372408, associated with KCNMB2-AS1 and SNPs associated with disease severity and could be used as genetic predictors in managing patients with HbE/β-thalassemia.
Non-compliance to iron chelation therapy in patients with transfusion-dependent thalassaemia
Factors affecting health-related quality of life and its association with the Xmn1-Gγ polymorphism among adolescents with transfusion-dependent beta thalassemia and HbE/β-thalassemia in East Coast…
Factors Affecting Health Related Quality of Life and Its Association with Xmn1 Gene Modifier among Transfusion-Dependent β-Thalassemia and HbE/β-Thalassemia Adolescent in East Coast Malaysia
Xmn1 gene modifiers is significantly associated with HRQoL which affects physical and emotional function among the patients, and contributed to new development of effective preventive strategies in the future.
Global Globin Network Consensus Paper: Classification and Stratified Roadmaps for Improved Thalassaemia Care and Prevention in 32 Countries
- Bin Hashim Halim-Fikri, C. Lederer, B. Zilfalil
- MedicineJournal of personalized medicine
- 31 March 2022
The proposed rubrics and accumulative scores will help analyse the performance and improvement of care, treatment, and prevention of haemoglobinopathies in the G GN and beyond and note the contribution of the GGN to a local and global reduction of disease burden.
Genetic Analysis of Beta Globin Gene (HBB) in Transfusion-Dependent HBE/β-Thalassemia Patients
The impact of genetic modifiers on genotype heterogeneity and clinical severity of the disease was showed and a better understanding of the mechanism underlying the variety of phenotypes of this disease may lead to better future management plans.
Eduvariome HVP Malaysia: Promoting Knowledge and Awareness on Thalassaemia among Secondary School Students in North-East of Peninsular Malaysia
The educational intervention done by MyHVP EduVariome programme proved to increase the knowledge of the participants about thalassaemia, and knowledge scores were significantly increased after the educational intervention.
rs9376092 is a biomarker of severe HbE/Beta thalassemia
The rs9376092 is a common biomarker of severe HbE/Beta thalassemia Malay, β 0 Thai-Chinese and Indonesian origin and the underlying mechanism needs further investigation.