Nurten Ozdemir

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Poly D,L-lactic acid (PLA) and its copolymers with glycolide PLGA 90:10 and 70:30 were polymerized under various conditions to yield polymers in the molecular weight range 12000-40000 daltons, as determined by gel permeation chromatography. Vancomycin hydrochloride was the hydrophilic drug of choice for the treatment of methicillin resistant Staphyloccoccal(More)
In this study, by preparing the solid dispersions of furosemide, a substance that is poor-soluble in water, with polyethylene glycol 6000, 10,000 and 20,000, the enhancement of the dissolution rate of furosemide has been aimed. Solid dispersions were prepared by the fusion method in proportions of 1:4, 1:6 and 1:10 (active material/polymer). The formation(More)
It is usually quite difficult to obtain zero order release rate kinetic from matrix system. The release of drug from matrix is usually inversely proportional to the square root of time. It is shown in previous works that the release kinetics from the matrix system are strongly dependent on the matrix geometry. In this work, we aimed at producing zero order(More)
For the purpose of enhancement the bioavailability of furosemide (FR), a floating dosage form with controlled release of FR was designed in this study. Because of the lower solubility of active material in the gastric medium, it was first enhanced by preparing an inclusion complex of FR with beta-cyclodextrin (beta-CD) in a 1:1 proportion using the kneading(More)
The purpose of this study was to improve the solubility and dissolution rate of sulfamethoxazole (SMZ) with inclusion compound of β-cyclodextrin (β-CD). The interaction between SMZ and β-CD in solution was studied by the phase-solubility method. The phase-solubility studies revealed the formation of inclusion complexes with poor solubility with an inclusion(More)
Some chemicals or thermal burns may result in abnormal reepithelialization by conjunctival epithelial cells and it causes different types of damage on the cornea surface. When reepithelialization does not occur, chronic inflammation and neovascularization develop, often leading to stroma scarring and/or ulceration. The aim of this study is to restore the(More)
The purpose of this study was to increase the solubility of furosemide (FR) with inclusion compound of beta-cyclodextrin (beta-CD). The interaction between FR and beta-CD in solution was studied by the solubility method. The phase solubility studies reveal a Bs-type diagram with an inclusion complex of 1:1 molar ratio and a stability constant of 823.5(More)
Floating dosage forms of acetylsalicylic acid, used for its antithrombotic effect, were developed to prolong gastric residence time and increase bioavailability. In the two-layer tablet formulation, hydroxypropyl methylcellulose (HPMC) of high viscosity and an effervescent mixture of citric acid and sodium bicarbonate formed the floating layer. The release(More)
The aim of this study was to investigate the effect of the formulation parameters on the release of water slightly soluble drug from the lipid matrices. Ibuprofen and hydrogenated cotton seed oil were used as the slightly soluble drug and matrice material, respectively. The preparations satisfying sustained release dosage form of Ibuprofen was also(More)
A congealable disperse phase encapsulation method was used to prepare controlled release lipid microspheres of sulphamethizole as a model drug. Hydrogenated cotton seed oil (HCSO) and stearic acid were employed as the lipid matrix materials. Tween 60 was the droplet stabilizer used to form microspheres. In in vitro dissolution tests, the drug release was(More)