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Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear Memory
Reactivated memory undergoes a rebuilding process that depends on de novo protein synthesis. This suggests that retrieval is dynamic and serves to incorporate new information into preexistingExpand
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Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia
Serotonin (5-HT) plays a critical role in modulating synaptic plasticity in the marine mollusc Aplysia and in the mammalian nervous system. In Aplysia sensory neurons, 5-HT can activate severalExpand
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Immunohistochemical Localization of Netrin-1 in the Embryonic Chick Nervous System
Netrin-1 has profound in vitro effects on the growth properties of vertebrate embryonic axons. In addition,netrin-1 mRNA is found in the floor plate of the embryonic nervous system, an intermediateExpand
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Induction of Neuronal Vascular Endothelial Growth Factor Expression by cAMP in the Dentate Gyrus of the Hippocampus Is Required for Antidepressant-Like Behaviors
The cAMP cascade and vascular endothelial growth factor (VEGF) are critical modulators of depression. Here we have tested whether the antidepressive effect of the cAMP cascade is mediated by VEGF inExpand
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A Novel Conditional Genetic System Reveals That Increasing Neuronal cAMP Enhances Memory and Retrieval
Consistent evidence from pharmacological and genetic studies shows that cAMP is a critical modulator of synaptic plasticity and memory formation. However, the potential of the cAMP signaling pathwayExpand
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N termini of apPDE4 isoforms are responsible for targeting the isoforms to different cellular membranes.
Phosphodiesterases (PDEs) are known to play a key role in the compartmentalization of cAMP signaling; however, the molecular mechanisms underlying intracellular localization of different PDE isoformsExpand
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Learning-Related Synaptic Growth Mediated by Internalization of Aplysia Cell Adhesion Molecule Is Controlled by Membrane Phosphatidylinositol 4,5-Bisphosphate Synthetic Pathway
Long-term facilitation in Aplysia is accompanied by the growth of new synaptic connections between the sensory and motor neurons of the gill-withdrawal reflex. One of the initial steps leading to theExpand
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Neuronal RNA granule contains ApCPEB1, a novel cytoplasmic polyadenylation element binding protein, in Aplysia sensory neuron
The cytoplasmic polyadenylation element (CPE)-binding protein (CPEB) binds to CPE containing mRNAs on their 3' untranslated regions (3'UTRs). This RNA binding protein comes out many important tasks,Expand
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Aged wild-type littermates and APPswe+PS1/ΔE9 mice present similar deficits in associative learning and spatial memory independent of amyloid load
APPswe+PS1/ΔE9 transgenic (Tg) mice with Aβ plaque formation in neocortex and hippocampus were evaluated in tests measuring exploratory activity, anxiety, and memory ability using open field testExpand
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Determination of Behavior and the Stimuli-dependent Transition of the Probability of Behavioral Expression: A Study on the Fluctuation of Behavioral State as Represented by the Level of Body Movement
The behavior of most animals is extremely complex. Despite accumulating knowledge about the mechanisms of neurons and nervous systems, which regulate these complex behaviors, we have littleExpand