Nuria Riera Diaz

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BACKGROUND The nociceptin/orphanin-FQ (or opioid receptor-like [ORL1]) receptor (NOP) is localized in the mesolimbic reward pathway and has been suggested to play a role in feeding, mood, stress, and addiction. Since its deorphanization in 1995, there has been a clear dichotomy in the literature regarding whether an agonist or antagonist would provide(More)
Positron emission tomography (PET) coupled to an effective radioligand could provide an important tool for understanding possible links between neuropsychiatric disorders and brain NOP (nociceptin/orphanin FQ peptide) receptors. We sought to develop such a PET radioligand. High-affinity NOP ligands were synthesized based on a(More)
Kappa opioid receptors and their endogenous neuropeptide ligand, dynorphin A, are densely localized in limbic and cortical areas comprising the brain reward system, and appear to play a key role in modulating stress and mood. Growing literature indicates that kappa receptor antagonists may be beneficial in the treatment of mood and addictive disorders.(More)
In this paper, an overview of the NEWSKY project is given. This project is funded by the European Commission within the 6th framework program and starts in January 2007. The NEWSKY project is a feasibility study to clarify if it is possible to establish a heterogeneous network for aeronautical communications which is capable to integrate different(More)
Currently, a lack of sufficient tools has limited the understanding of the relationship between neuropsychiatric disorders and the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor. Herein, we describe the discovery and development of an antagonist NOP receptor occupancy (RO) tracer and a novel positron emission tomography (PET) radioligand suitable to(More)
AIM To determine the opinion of head teachers on the educational and logistical characteristics required for a basic cardiopulmonary resuscitation (b-CPR) programme for secondary school teenagers to succeed. MATERIAL AND METHODS The study was carried out in Barcelona which has 227 public and private secondary schools. Secondary school is started at 12(More)
In this paper, we study the provision of broadband interactive services to passengers of Korean high-speed train in the ISM 2.4 GHz band. We address in particular the design of tunnel gap-fillers (GFs) able to provide bi-directional connectivity to train-based terminals. The work has been developed in the broader context of interactive services provision(More)
The railroad satellite channel is characterized by frequent signal outages due to tunnels, bridges and electrical trellises. While for medium/long tunnels the main option to offer reliable and uninterrupted connectivity deals with the adoption of gap-filling techniques, signal outages due to small bridges/tunnels or electrical trellises can be faced with(More)
This annual article presents new drugs and biologics that were launched or approved for the first time during the previous year. In 2008, 31 new medicines-this figure includes both drugs and biologics for therapeutic use as well as new diagnostic agents-reached their first markets. Line extensions (new indications, new formulations and new combinations of(More)