Nuria Calvo

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The neostriatum is one of the areas with relatively high levels of glial cell line-derived neurotrophic factor (GDNF) messenger RNA expression in the developing and adult brain. GDNF expression in the neostriatum has been suggested to be involved in promoting the survival of nigral dopaminergic neurons, acting as a target-derived neurotrophic factor.(More)
The neuroprotective effect of tachykinins against excitotoxic death of cholinergic neurons was studied in rat striatal cell cultures. Quinolinic acid (QUIN) and kainic acid (KA) produced a dose dependent decrease in choline acetyltransferase activity, but KA was more potent. Our results show that substance P (SP) totally reversed the toxicity induced by 125(More)
In the present work we have characterized a possible mechanism leading to the early survival of neostriatal cholinergic neurons after quinolinic acid injection. Different doses of quinolinic acid were injected in rat neostriatum and two different parameters were analysed 7 days after the lesion: choline acetyltransferase (ChAT) activity and nerve growth(More)
Meteorological observations made on board ships prior to 1854 have until now been overlooked in climatological research largely as a result of the lack of rigorous abstraction and treatment criteria. However, the CLIWOC project has shown that millions of potentially valuable observations have been preserved throughout Europe in the many logbooks that were(More)
Creating university spin-offs (USOs) should be one of the cornerstones of a country’s business development. Yet a number of studies have identified two factors that limit their growth: access to funding difficulties and a lack of management skills among entrepreneurial teams. In order to identify potential solutions for the latter of those factors, an(More)