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Mapping the human DC lineage through the integration of high-dimensional techniques
Tracing development of the dendritic cell lineage Dendritic cells (DCs) are important components of the immune system that form from the bone marrow into two major cell lineages: plasmacytoid DCs andExpand
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Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingestedExpand
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Induced‐Pluripotent‐Stem‐Cell‐Derived Primitive Macrophages Provide a Platform for Modeling Tissue‐Resident Macrophage Differentiation and Function
Summary Tissue macrophages arise during embryogenesis from yolk‐sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficientExpand
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Human Regulatory B Cells Combine Phenotypic and Genetic Hallmarks with a Distinct Differentiation Fate
Regulatory B cells (B-reg) produce IL-10 and suppress inflammation in both mice and humans, but limited data on the phenotype and function of these cells have precluded detailed assessment of theirExpand
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Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage
Dendritic cells (DC) are currently classified as conventional DCs (cDCs) and plasmacytoid DCs (pDCs). Through a combination of single-cell transcriptomic analysis, mass cytometry, in vivo fateExpand
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The immune system in the elderly: a fair fight against diseases?
The immune system is a very dynamic network, consisting of various innate and adaptive cells acting via direct cell–cell contact, as well as indirect messaging mediated by soluble factors. Changes inExpand
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Multi‐parametric phospho‐flow cytometry: A crucial tool for T lymphocyte signaling studies
Tools such as protein immunoblotting have proven benefits for investigating T lymphocyte signaling but have several drawbacks such as the number of cells required and the difficulty of distinguishingExpand
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