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BACKGROUND Oxidative stress in atherosclerosis produces H2O2 and triggers the activation of nuclear factor kappa beta (NF-κB) and increase of inducible nitric oxide synthase (iNOS). The formation of vasa vasorum occurs in atherosclerosis. Vasa vasorum angiogenesis is mediated by VEGFR-1 and upregulated by hypoxia-inducible factor-1α (HIF-1α). The newly(More)
License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information(More)
OBJECTIVES To know whether Scurrula atropurpurea is able to modulate total plasma nitrate/nitrite levels, decrease endothelial damage, and increase endothelial progenitor cells (EPCs) in hypertensive rats. MATERIALS AND METHODS The rats were divided in 5 groups: control (normotensive) group, Desoxy cortico sterone (DOCA)-salt hypertensive group, and three(More)
AIM To evaluate effect of hypertension on retinal ganglion cell (RGC) apoptosis, intraocular pressure (IOP), and the activation of endothelin-1 (ET-1) signaling pathway in central retinal artery (CRA) in rats. METHODS The experimental study was performed on 20 male Sprague Dawley rats that were divided into control group, and hypertension groups. The(More)
The increase of heart failure prevalence on menopausal women was correlated with the decrease of estrogen level. The aim of this study is to investigate the effects of ceplukan leaf (Physalis minima L.), which contains phytoestrogen physalin and withanolides, on ventricular TNF-α level and fibrosis in ovariectomized rats. Wistar rats were divided into six(More)
OBJECTIVE The purpose of the present study was to analyze the effects of glucose and shear stress on the morphology and density of endothelial cells, actin filamen, and the expression of VE-cadherin. METHODS After confluency of endothelial cells (3-4 days), 22 mM of d-glucose was administered for 7 days. Endothelial cells were exposed to shear stress of(More)
Advanced glycation end products (AGEs) are known to increase in osteoporosis. Methylglyoxal is AGEs precursor that is toxic to osteoblasts. Methylglyoxal toxicity in osteoblasts involves oxidative stress. The involvement of reactive oxygen species (ROS) in changes of MC3T3E1 preosteoblast cell line morphology caused by methylglyoxal exposure is still(More)
Channa striata is considered as a potential food, because it is known to be used as the treatment of wounds, reduced pain, and as additional energy during illness. This fish is always consumed by rural peoples to having good medicinal qualities. But why this can happen need to be explored. This study was undertaken to determine the nutrients content and(More)
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