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Intracellular pathogens employ several strategies for iron acquisition from host macrophages for survival and growth, whereas macrophage resists infection by actively sequestering iron. Here, we show that instead of allowing macrophage to sequester iron, protozoan parasite Leishmania donovani (LD) uses a novel strategy to manipulate iron uptake mechanisms(More)
Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing upregulation of the iron transporter transferrin, the top differentially expressed gene compared with tissue-specific progenitors. Direct interrogation of iron uptake demonstrated that(More)
The immature oocyte and unfertilized eggs of Urechis caupo, a marine echiuroid worm, contain many nuclear bodies and a main nucleolus. These bodies are similar to prenucleolar bodies of other materials with respect to their origin, structure, cytochemical and biochemical characteristics. They are formed in large numbers during the diffuse diplotene stage,(More)
Rates of DNA synthesis in root tip cells of diploid and autotetraploid snapdragon (Antirrhinum majus) seedlings and in diploid and tetraploid (mononucleate and bidiploid-nucleate) regenerating mouse-liver cells have been studied. The increase in this rate in the tetraploid cells is closely correlated with the increase in nuclear surface area, but not with(More)
Nucleoli from unfertilized Urechis eggs, labeled with tritiated RNA precursors, have been isolated for simultaneous autoradiographic localization and biochemical analysis of labeled RNA. The production of the ribosomal RNA precursor (38S) and its first cleavage occur at the fibrillar core region of the nucleolus. The products, predominantly 30S RNA, are(More)