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OBJECTIVES To determine whether CT can depict early perfusion changes in lung cancer treated by anti-angiogenic drugs, allowing prediction of response. METHODS Patients with non-small cell lung cancer, treated by conventional chemotherapy with (Group 1; n = 17) or without (Group 2; n = 23) anti-vascular endothelial growth factor (anti-VEGF) drug(More)
Among the various imaging modalities available, CT has remained over time the core imaging technique for the evaluation of respiratory disorders. The recent advent of dual-source CT offers innovative approaches to investigate thoracic diseases, based on the use of one or two tubes as well as single or dual energy to scan the entire thorax. Two major options(More)
Before the advent of fast-scanning multidetector-row computed tomography (CT) technology, thoracic CT studies were exclusively used for the morphologic assessment of thoracic organs, as the concurrent examination of the heart was hampered by image degradation from cardiac motion artifacts. The introduction of fast rotation speed and dedicated cardiac(More)
PURPOSE To evaluate whether dual-energy CT angiography (DE-CTA) could identify links between morphologic and functional abnormalities in chronic pulmonary thromboembolism (CPTE). MATERIALS AND METHODS Seventeen consecutive patients with CPTE without underlying cardio-respiratory disease were investigated with DE-CTA. Two series of images were generated:(More)
RATIONALE AND OBJECTIVES To investigate the accuracy of dual-energy computed tomography in the depiction of perfusion defects in patients with acute pulmonary embolism (PE). MATERIALS AND METHODS One hundred seventeen consecutive patients with clinical suspicion of acute PE underwent dual-energy multidetector computed tomographic (CT) angiography of the(More)
Recent technological advances in multidetector computed tomography (CT) have led to the introduction of dual-source CT, which allows acquisition of CT data at the same energy or at 2 distinct tube voltage settings during a single acquisition. The advantage of the former is improvement of temporal resolution, whereas the latter offers new options for CT(More)
PURPOSE To evaluate the impact of iterative reconstruction on the detectability of clots. METHODS AND MATERIALS Fifty-three patients were enrolled in a study comparing reduced-dose and full-dose images, available from the same dual-source data set. From each acquisition, three series of images were generated: (1) full-dose images (from both tubes),(More)
PURPOSE To determine the energy levels that provide optimal imaging of thoracic circulation at dual-energy computed tomographic (CT) angiography with reduced iodine load in comparison with a standard technique. MATERIALS AND METHODS The institutional review board approved the study with waiver of patient consent. Eighty patients underwent a dual-source,(More)
PURPOSE To assess tumor perfusion with multi-detector row computed tomography (CT) in patients with non-small cell lung carcinoma and to correlate CT findings with pathologic results. MATERIALS AND METHODS This study was approved by the local Ethics Committee, and all patients provided written informed consent, which included information on the radiation(More)
OBJECTIVE To evaluate image quality of dual-source computed tomography (CT) angiograms acquired with high temporal resolution and high pitch modes. METHODS Two groups of 70 consecutive patients underwent chest CT angiography with dual-source, single-energy CT, with an 83-ms temporal resolution and a pitch of 2 (group 1) or a pitch of 3 (group 2).(More)