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Four factors make it challenging to manage semiconductor fabrication facility ~“fabs”! projects: technical complexity of the product design, need to compress the project duration, need to reduce upfront costs, and unexpected project changes. The strategies employed by practitioners to cope with these challenges form an intricate puzzle. We empirically(More)
The use of molecularly targeted agents has dramatically improved the prognosis of defined subsets of patients with non-small-cell lung cancer harboring somatically activated oncogenes, such as mutant EGFR or rearranged ALK. However, after initial marked responses to EGFR or ALK tyrosine kinase inhibitors (TKIs), almost all patients inevitably progress due(More)
This study investigates the implementation of design reuse and buffers in developing the infrastructure of hightech production facilities Design reuse entails using the same systems architecture from one project to the next. Design buffers involve building slack into a proven systems architecture to absorb foreseeable change requests. Choosing the(More)
Movies are one of the biggest sources of entertainment, in individual and social contexts, and increasingly accessible as enormous collections of videos and movies over the Internet, in social media and interactive TV. These richer environments demand for new and more powerful ways to search, browse and view videos and movies, that may benefit from video(More)
This paper presents a process simulation model representative for design development of a building system in an unpredictable environment. Unpredictability means that design criteria are prone to change as design development unfolds. The model was implemented with a discrete-event simulation engine based on event graphs. Events capture moments when tasks(More)
The antioxidant activity of the phenolic compounds present in industrial black liquors obtained from the two cooking processes (kraft and sulphite) used in Portugal to produce Eucalyptus globulus pulp was evaluated. The black liquors treated at several pH values were extracted with ethyl acetate. Phenolic fractions were further separated by liquid(More)
Wood density and pulp yield are key parameters in the evaluation of tree productivity and quality for pulping and their relationships are of high practical importance. The influence of wood density on pulp yield and other pulp quality parameters was investigated using Acacia melanoxylon and its natural variability as a case study. Twenty trees were(More)