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The use of molecularly targeted agents has dramatically improved the prognosis of defined subsets of patients with non-small-cell lung cancer harboring somatically activated oncogenes, such as mutant EGFR or rearranged ALK. However, after initial marked responses to EGFR or ALK tyrosine kinase inhibitors (TKIs), almost all patients inevitably progress due(More)
Technology-mediated home care is attractive for older people living at home and also for their carers. It provides the information necessary to give confidence and assurance to everyone interested in the well-being of the older person. From a care delivery perspective, however, widespread deployment of home care technologies presents system developers with(More)
This paper discusses what knowledge specialty contractors may contribute to the early design of architecture, engineering, and construction (AEC) products. In current practice, specialty contractors are seldom involved in the early design effort, but evidence suggests that their early involvement is increasing. Lean construction theory advocates this(More)
Specialty contractors have knowledge to contribute to the early design of architecture, engineering, and construction (AEC) products. In current practice, however, they are seldom involved in early design, but evidence suggests that their early involvement is increasing. Lean construction theory advocates such involvement. The practice of involving(More)
Movies are one of the biggest sources of entertainment, in individual and social contexts, and increasingly accessible as enormous collections of videos and movies over the Internet, in social media and interactive TV. These richer environments demand for new and more powerful ways to search, browse and view videos and movies, that may benefit from video(More)
Four factors make it challenging to manage semiconductor fabrication facility ͑ " fabs " ͒ projects: technical complexity of the product design, need to compress the project duration, need to reduce upfront costs, and unexpected project changes. The strategies employed by practitioners to cope with these challenges form an intricate puzzle. We empirically(More)
Wood density and pulp yield are key parameters in the evaluation of tree productivity and quality for pulping and their relationships are of high practical importance. The influence of wood density on pulp yield and other pulp quality parameters was investigated using Acacia melanoxylon and its natural variability as a case study. Twenty trees were(More)