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The Yeast search for transcriptional regulators and consensus tracking (YEASTRACT) information system (www.yeastract.com) was developed to support the analysis of transcription regulatory associations in Saccharomyces cerevisiae. Last updated in September 2007, this database contains over 30 990 regulatory associations between Transcription Factors (TFs)(More)
Efforts using computational algorithms towards the enumeration of the full set of miRNAs of an organism have been limited by strong reliance on arguments of precursor conservation and feature similarity. However, miRNA precursors may arise anew or be lost across the evolutionary history of a species and a newly sequenced genome may be evolutionarily too(More)
MOTIVATION The ability to identify complex motifs, i.e. non-contiguous nucleotide sequences, is a key feature of modern motif finders. Addressing this problem is extremely important, not only because these motifs can accurately model biological phenomena but because its extraction is highly dependent upon the appropriate selection of numerous search(More)
MOTIVATION Logical (Boolean or multi-valued) modelling is widely used to study regulatory or signalling networks. Even though these discrete models constitute a coarse, yet useful, abstraction of reality, the analysis of large networks faces a classical combinatorial problem. Here, we propose to take advantage of the intrinsic modularity of inter-cellular(More)
MOTIVATION The computational search for novel microRNA (miRNA) precursors often involves some sort of structural analysis with the aim of identifying which type of structures are prone to being recognized and processed by the cellular miRNA-maturation machinery. A natural way to tackle this problem is to perform clustering over the candidate structures(More)
Motivation: Models of discrete concurrent systems often lead to huge and complex state transition graphs that represent their dynamics. This makes difficult to analyse dynamical properties. In particular, for logical models of biological regulatory networks, it is of real interest to study attractors and their reachability from specific initial conditions,(More)
In recent years, especially after the completion of genome sequencing projects for various organisms, there has been a growing interest in the study of regulation and gene expression mechanisms. The amount of data available makes it unfeasible to pursue a manual analysis calling for some sort of automatic processing. In this context, bioinformatics tools(More)
1 APPENDIX A In this appendix, we present additional material concerned with the methods used and the results obtained. In particular, we describe the way in which statistical validation of the selected motifs was performed, and the assumptions that were used for this computation. We also present and discuss the result of applying the proposed method to the(More)
Background: Eucalyptus is the world's most widely planted hardwood tree. Its outstanding adaptability and growth have made them a global renewable resource of fibre and energy. Their commercial value motivates studies over their genome and genetic regulation aiming to improve the wood quality. MiRNAs are important molecules in the genetic regulation. Their(More)
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