Nuno A. Costa

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Intravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of circulating T-cells and reduced activity of CD4 + Foxp3+ regulatory T-cells (Tregs) reflected by lower CD25(More)
In human systemic lupus erythematosus (SLE), diverse autoantibodies accumulate over years before disease manifestation. Unaffected relatives of SLE patients frequently share a sustained production of autoantibodies with indiscriminable specificity, usually without ever acquiring the disease. We studied relations of IgG autoantibody profiles and peripheral(More)
This work examines the performance of three formaldehyde scavengers in wood-based panels. Sodium metabisulfite, ammonium bisulfite and urea were applied in different physical forms during particleboard production, and the resulting physico-mechanical properties (internal bond strength, thickness swelling, density and moisture content) and formaldehyde(More)
This paper studies the performance of scavengers on Volatile Organic Compound (VOC) emissions from wood-based composites. Particleboards made from maritime pine (Pinus pinaster Ait.) and European poplar (Populus spp.) were produced with a UF resin doped with melamine and two scavengers, sodium metabisulfite and urea. VOC emission was measured according to(More)
Active regulatory T-cells contribute to broadened T-cell repertoire diversity in ivIg-treated SLE patients Nuno Costa, Ana E Pires, Ana M Gabriel, Luiz F Goulart, Clara Pereira, Barbara Leal, Ana C Queiros, Wahiba Chaara, Maria F Moraes-Fontes, Carlos Vasconcelos, Carlos Ferreira, Jorge Martins, Marina Bastos, Maria J Santos, Maria A Pereira, Berta Martins,(More)
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