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BACKGROUND Activin B has been reported to promote the proliferation and migration of keratinocytes in vitro via the RhoA-JNK signaling pathway, whereas its in vivo role and mechanism in wound healing process has not yet been elucidated. PRINCIPAL FINDINGS In this study, we explored the potential mechanism by which activin B induces epithelial wound(More)
BACKGROUND Cocaine addiction may involve complex neuroadaptations, including many changes of genes expression. Dopamine D3 receptors play an important role in cocaine addiction; however, its role in cocaine induced gene expression change is poorly understood. To identify the changes in gene expression induced by repeated cocaine exposure through D3 dopamine(More)
Interleukin-2 (IL-2) can stimulate T cell proliferation and differentiation when binding to its receptor on T cells. It produces a marked effect by enhancing the cytotoxicity of CD8+ T cells and natural killer cells. Granulocyte-macrophage colony stimulating factor (GM-CSF) is associated with many cells proliferation, such as dendritic cells, macrophages.(More)
OBJECTIVE To study the role of dopamine receptors in the regulation of the activity of transcription factor cAMP response element-binding protein (CREB) after cocaine treatment. METHODS By using dopamine receptor antagonists SCH23390 and nafadotride, the activation of CREB by D1 and D3 dopamine receptors after cocaine treatment and role of extracellular(More)
OBJECTIVE To analyse and compare the chemical compositions in the volatile oil from Utramicro-powder and Common Grinding Powder of Cinnamomum. METHODS The volatile oil was extracted by steam-stilling and analyzed by GC-MS. The relative content of each component was calculated by area normalization method. RESULTS 34 and 19 peaks were isolated from(More)
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