Nozomu Hikino

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Adverse reactions to DTP became a social problem in Japan in 1975 which brought a fall of immunization rates and an epidemic of pertussis which had its peak in 1979. Development of a new DTP vaccine with less adverse reactions was urgently needed and an acellular pertussis vaccine was developed which has replaced whole cell pertussis vaccines. More than 15(More)
Immunoglobulin-bearing peripheral blood lymphocytes were examined in 20 children with Kawasaki disease and in 13 healthy control children. Routine laboratory tests were also performed. IgG-bearing lymphocytes, IgA-bearing lymphocytes, and IgM-bearing lymphocytes increased in children with Kawasaki disease when compared with those of controls. Measurement of(More)
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