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The formation of the neuromuscular junction (NMJ) is orchestrated by the muscle-specific receptor tyrosine kinase MuSK and by neural agrin, an extracellular activator of MuSK. We previously showed that the MuSK-interacting protein Dok-7 is essential for neuromuscular synaptogenesis, although the mechanisms by which Dok-7 regulates MuSK activity and promotes(More)
Cholic acid (CA) feeding of farnesoid X receptor (Fxr)-null mice results in markedly elevated hepatic bile acid levels and liver injury. In contrast, Fxr-null mice fed cholesterol plus CA (CA+Chol) do not exhibit liver injury, and hepatic bile acid levels and bile acid pool size are reduced 51 and 40%, respectively, compared with CA-treated Fxr-null mice.(More)
The complement system is important for the host defence against infection as well as for the development of inflammatory diseases. Here we show that C1q/TNF-related protein 6 (CTRP6; gene symbol C1qtnf6) expression is elevated in mouse rheumatoid arthritis (RA) models. C1qtnf6(-/-) mice are highly susceptible to induced arthritis due to enhanced complement(More)
The purpose of this study was to investigate how touch screen response time affected user's psychological state and task performance. Ten male participants performed numeric entry task on the touch screen under six different conditions by crossing speed of touch screen response for pressing buttons and of switching pages. Results suggested that the touch(More)
The objective of this study was to examine the differences in mental workload to computer-based tasks between men and women. Twelve female and twelve male students participated in the study. They performed a modified mirror tracing task and a mental arithmetic task. Mental workload was measured by physiological variables, subjective measurement and(More)
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