Nozomi Aruga

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We examined the effects of tranilast, an anti-allergic agent, on hypersensitive inflammation and on morphology and functions of fibroblasts. In vivo, tranilast suppressed the content of collagen in granulation tissue of hypersensitive granulomatous inflammation induced by methylated bovine serum albumin (m-BSA) in rats. In culture, tranilast inhibited the(More)
Several systematic reviews have reported that flow mediated dilatation (FMD) was significantly increased in subjects after ingestion of chocolate that contains flavan-3-ols; however, the mechanisms responsible for this effect are not clear. In this study, we evaluated the effects of a single oral dose of flavan-3-ols on the systemic circulation and(More)
Observation and recording methods of the ocular-fundus in small laboratory animals were studied using the industrial endoscope and VTR systems, respectively. The ocular-fundus was observed widely, brightly and clearly in the usual animal facility. In addition, the ocular-fundus was recorded easily and it was possible to examine the ocular-fundus recorded by(More)
Blood cell and bone marrow cell counts were carried out for male C.B-17 scid/scid (SCID) mice aged 3, 6, 9, 18 and 26 weeks and the values were compared with those in C.B-17 +/+ (C.B-17) mice. In the peripheral blood, SCID mice had markedly low numbers of leucocytes and lymphocytes throughout the study. In the bone marrow, SCID mice had relatively low(More)
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