Norman Schanz

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Infant house mice, Mus musculus, produce ultrasonic calls that reliably lead to retrieval by adult mice. While individual differences in calls have been demonstrated both among and within species, the influences of age and sex on call characteristics have not been systematically investigated in mice. This study examined the influences of age, sex, and(More)
Consumers of marijuana typically feel a strong, compulsive desire to consume food. Although past research revealed that the CB1 cannabinoid receptor is a potent regulator of food intake, the functional presence of neuronal CB2 cannabinoid receptors in the brain has been controversial. The role of CB2 receptors in food and alcohol consumption and the(More)
Marijuana use activates cannabinoid receptors (CB-Rs) producing several behavioral effects related to addiction, mood, and appetite. We investigated the association between CNR2 gene, which encodes cannabinoid CB2 receptor (CB2-R) and eating disorders in 204 subjects with eating disorders and 1876 healthy volunteers in Japanese population. The effect of(More)
Ultrasonic calls produced by young mice reliably elicit investigation and retrieval by adults. While there are large individual differences in the characteristics of these calls, little work has been done to partition that variation. We completed a 4 x 4 diallel cross and Hayman analyses on several characteristics of these cries. The major result was the(More)
Previous studies have demonstrated alterations in maternal retrieval behavior as a result of direct cocaine exposure. To establish the influence of prenatal cocaine exposure on pup retrieval, we exposed pups of three F1 genotypes by injecting their mothers (all C57BL/10J strain) with 20 mg/kg cocaine hydrochloride or saline subcutaneously on gestation days(More)
Estimates are that as many as 44,000 humans are exposed to cocaine in utero per year. In this study we examined the effects of prenatal cocaine exposure on one aspect of the mother-infant relationship in mice, infant ultrasonic calls. We mated C57BL/10J female mice with males of three different inbred strains (producing pups of three different F(1)(More)
This study shows that the BTBR T+tf/J mouse, a model for autism spectrum disorder (ASD), has increased levels of the stress hormone corticosterone, when compared to C57BL/6J mice. In addition, we have shown that tail suspension of the BTBR produces a heightened anxiety response in the elevated plus maze. These results suggest that the BTBR mouse is(More)
Autism spectrum disorders (ASDs) are heterogenous neurodevelopmental disorders characterized by impairment in social, communication skills and stereotype behaviors. While autism may be uniquely human, there are behavioral characteristics in ASDs that can be mimicked using animal models. We used the BTBR T+tf/J mice that have been shown to exhibit(More)
Cyclosporine A (CsA) is an immunosuppressive agent, which also causes hypertension. The effect of CsA on vascular responses was determined in Sprague-Dawley rats and rat aortic rings. Male rats weighing 250-300 g were given either CsA (25 mg/kg/day) in olive oil or vehicle by intraperitoneal (ip) injection for 7 days. CsA administration produced a 42%(More)
Infant mice produce ultrasonic calls that may elicit retrieval by adult mice. Age-related differences and genetic effects, such as additivity and directional dominance, have been found for most call characteristics at 3 days of age. Significant maternal effects have been reported for calling rate. However, little is known about how the influence of these(More)