Norman Brenner

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[125I]L-735,286, a new potent and AT1-selective nonpeptide angiotensin II receptor radioligand, bound saturably to whole adrenal membranes. Scatchard and Hill plot analysis indicates a single class of high affinity (Kd = 0.5 nM) binding sites. The potencies of various angiotensin II agonists and antagonists in displacing specific [125I]L-735,286 binding are(More)
Several computers have been built experimentally which incorporate a large number of identical CPUs. One example known to this author contains 65 identical microprocessors: one is the “master” and issues orders (normally identical or nearly so) to the other 64, called “slaves”. The master and each slave has its own storage unit. It(More)
APL includes a few primitives to permit searching of strings for single characters, principally the dyadic iota. APL2 adds iota underline. This latter function will find all occurrences of a given string in a longer string. Sometimes, however, more elaborate searching is needed; for example, searching for strings of variable length, searching for any of(More)
The potential for imaging the angiotensin II receptor was evaluated using the radioiodinated peptide antagonist [125I][Sar1, Ile8)angiotensin II. The radioligand provides a receptor-mediated signal in several tissues in rat (kidneys, adrenal and liver). The receptor-mediated signal of 3% ID/g kidney cortex should be sufficient to permit imaging, at least(More)
An experimental full screen editor has been written in APL for IBM 3270 display terminals, based on the following principles: • a small command repertoire, based on APL syntax • an undo facility for correcting mistakes • internal dependence upon a small number of editing primitives As written, the editor contains two major commands,(More)
A high affinity radioligand for bradykinin B2 receptors was prepared by coupling an activated ester of [125I]4-iodobenzoic acid to the amino terminus nitrogen of the potent B2 antagonist HOE 140. The ligand, [125I]para-iodophenyl HOE 140 ([125I]PIP HOE 140), bound to a homogeneous set of sites in guinea pig ileal membranes with an equilibrium dissociation(More)
Our group at IBM Yorktown Research has written a number of tool programs for VLSI design, all in APL. Several crucial algorithms were speeded up by recoding them in Fortran and Assembler Language. For example, the algorithm for complementation of a Boolean expression (which can sometimes have thousands of terms in dozens of variables) is 5 times faster in(More)
The VM/SP System Editor XEDIT is used to edit APL objects. Two approaches are possible: with an APL function, or with an exec written in REXX (the new VM/SP System Interpreter). The advantages of the latter are that nothing need be copied into the user's workspace, and that APL code can be executed from XEDIT, and XEDIT commands from APL. No new Auxiliary(More)