Noriyuki Yanagita

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The outcome of unilateral sudden deafness with and without vertigo was evaluated according to the severity of the initial hearing loss, the shape of the audiogram, and other variables. The subjects for this investigation were 1313 patients who had presented to the authors' university hospital from 1972 to 1990 within 2 weeks of the onset of hearing loss.(More)
The influence of age and sex on auditory improvement after stapes surgery was investigated retrospectively on 127 otosclerotic ears (99 subjects) that were followed up for 6 months postoperatively. The prostheses used were the Shuknecht-type Teflon wire piston (87 ears), the House-type wire loop (29 ears), and the Cawthone-type Teflon piston (11 ears).(More)
The immunoregulatory action of saikosaponin-d (SSd), which was isolated from the root of Bupleurum falcatum L. and has a steroid-like structure, was examined on splenic T lymphocytes of C57BL/6 mice. SSd displayed a definite action in vitro to bidirectionally control the growth response of T lymphocytes stimulated by concanavalin A, anti-CD3 monoclonal(More)
Factors affecting auditory improvement after stapes surgery were investigated retrospectively on a study group of 106 otosclerotic ears (86 subjects). While the closure of the air-bone (A-B) gap after surgery was good at 2 kHz and 4 kHz, it was poor at 8 kHz and at frequencies lower than 1 kHz. Under 1 kHz, the lower the frequency, the worse the A-B gap(More)
Nationwide epidemiological surveys of sudden deafness were conducted in 1972 and 1987 by the Research Committee of the Japanese Ministry of Health and Welfare. Sex ratio (men over women) of definite cases of sudden deafness was 1.19 in 1972 and 0.96 in 1987. The number of patients with sudden deafness was more common between 30 and 49 years of age in 1972,(More)
Although sudden deafness has many causes, it is often a sensorineural hearing loss with an abrupt onset and unknown origin. The majority of these latter cases are unilateral in their occurrences, while bilateral simultaneous involvement is rarely seen. During the past 13 years, we have treated 997 patients with sudden deafness. All patients were seen at our(More)
After recording transiently evoked otoacoustic emissions (TEOAEs) to a click stimulus in guinea pigs by using the IL088 which was developed by Bray and Kemp (1987) for easy recording and analysis of TEOAE, the changes after intravenous administration of furosemide (30 mg/kg or 50 mg/kg) were examined. The wave of the TEOAE could be detected from 20 of 24(More)
We used a guinea pig model to investigate the effect of round window membrane rupture on endolymphatic and perilymphatic pressures under conditions known to increase these pressures: anoxia, hypercapnia, increased intracranial pressure, and occlusion of the vein of the cochlear aqueduct. When the round window membrane was not ruptured, increases in(More)
Aspirin and other salicylates influence otoacoustic emissions (OAEs), but changes in transiently evoked OAEs (TEOAEs) following aspirin intake have not been studied experimentally. We examined the changes in TEOAEs, together with auditory brainstem responses (ABRs), in guinea pigs before and after the intravenous injection of aspirin (100 and 400 mg/kg).(More)