Noriyo Kawasumi

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With the Akeno Giant Air Shower Array (AGASA), 581 cosmic rays above 10 19 eV, 47 above 4 × 10 19 eV, and 7 above 10 20 eV are observed until August 1998. Arrival direction distribution of these extremely high energy cosmic rays has been studied. While no significant large-scale anisotropy is found on the celestial sphere, some interesting clusters of(More)
Three microsome enzymes are involved in voriconazole (VRCZ) metabolism, CYP2C19, CYP3A4 and CYP2C9, and subjects classified as poor metabolizers (PM), which would include about 20% of Japanese population, had higher serum VRCZ concentrations than other subjects. Also, because VRCZ appears hepatotoxicity and visual disturbance in side effect, VRCZ must be(More)
With the Akeno Giant Air Shower Array (AGASA), 581 cosmic rays above 10 19 eV, 47 above 4 × 10 19 eV, and 7 above 10 20 eV are observed until August 1998. Arrival direction distribution of these extremely high energy cosmic rays has been studied. While no significant large-scale anisotropy is found on the celestial sphere, some interesting clusters of(More)
There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest that HDL and gamma globulin contribute(More)
We report a rst result on the cosmic ray energy spectrum above 3 10 18 eV measured by the Akeno Giant Air Shower Array (AGASA) from July 1990 to February 1994. The analysis method and the energy resolution of the AGASA experiment are described in some detail. The attening of the spectrum around 10 19 eV (ankle) is observed with a signicance of 2.9. If we(More)
A very energetic cosmic ray of energy about (1.72.6)10 20 eV was observed by the Akeno Giant Air Shower Array (AGASA) on December 3, 1993 from the direction of galactic longitude l=131 and galactic latitude b=-41 within an error circle of 1.0 radius. Shower characteristics such as lateral distribution and arrival time spread of charged particles, and(More)
We will report the observations of TeV gamma ray flares from Markarian 501 using Telescope Array Prototype. The observation were carried out continuously from the end of March to the end of July in 1997. The energy spectrum, and the time variation of the gamma ray intensities are shown. The intensity has been changed by the order of magnitude in this period(More)
BACKGROUND One of the major adverse events of caspofungin and micafungin is hepatotoxicity, however, there are few reports compared the incidence of hepatotoxicity between caspofungin and micafungin. Herein, the primary objective of this study was to compare the incidence of hepatotoxicity between caspofungin and micafungin treatments for patients with(More)
Voriconazole (VRCZ), a broad-spectrum triazole, is served in two dosage forms-injection and oral. VRCZ is difference dosage of oral and intravenous administration writing a medical package insert in Japan. 6 mg/kg intravenous injection (IV) twice daily for first day as initial loading dose, followed by 3-4 mg/kg IV twice daily between meals is recommended.(More)
We examined the peck concentration (Cmax)/minimal inhibitory concentration (MIC) and the clinical efficacy in methicillin-resistant Staphylococcus aureus (MRSA) pneumonia and Gram-positive cocci bacteremia. We evaluated arbekacin (ABK) on 22 cases of pneumonia and 10 cases of bacteremia in Aichi Medical University Hospital between August 2008 and July 2011,(More)