Noriuki Nagahara

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Recently, redox-regulated biological reactions have been elucidated. In the regulation of these reactions, redox-sensing molecular switches function as unique biological machineries that modulate the functional proteins present in enzymes, transcriptional factors, sensor proteins, and transcriptional factor modulators. The redox-sensing cysteine residues(More)
The expression and activity of cystathionine γ-lyase (CST) and 3-mercaptopyruvate sulfurtransferase (MPST) were investigated in the human neoplastic cells lines: astrocytoma U373, neuroblastoma SH-SY5Y, melanoma A375, and melanoma WM35. Gene expression analysis demonstrated that the investigated neoplastic cells showed the expression of MPST and what is(More)
This special issue is devoted to professor Toshihiko Ubuka (1934–2008), a distinguished Japanese biochemist who, in his scientific life, researched the metabolism and function of cysteine, sulfur nutrition, modification and renaturation of proteins and the possible significance of cysteine metabolites in antioxidation processes in liver cell mitochondria.(More)
The oligomeric state of human porphobilinogen synthase (PBGS) [EC.4.2.1.24] is homooctamer, which consists of conformationally heterogenous subunits in the tertiary structure under air-saturated conditions. When PBGS is activated by reducing agent with zinc ion, a reservoir zinc ion coordinated by Cys223 is transferred in the active center to be coordinated(More)
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