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Development in the cynomolgus macaque following administration of ustekinumab, a human anti-IL-12/23p40 monoclonal antibody, during pregnancy and lactation.
- Pauline L. Martin, C. Sachs, +4 authors G. Treacy
- Birth defects research. Part B, Developmental and…
- 1 October 2010
BACKGROUND Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of interleukin (IL) 12 and IL-23 and inhibits their pharmacological activity. To evaluate potential effects of… Expand
Alterations in male infant behaviors towards its mother by prenatal exposure to bisphenol A in cynomolgus monkeys (Macaca fascicularis) during early suckling period
- Akiko Nakagami, T. Negishi, K. Kawasaki, N. Imai, Takamasa Koyama
- Biology, Medicine
- 1 September 2009
Bisphenol A (BPA) is an environmental chemical with physiological potencies that cause adverse effects, even at environmentally relevant exposures, on the basis of a number of studies in experimental… Expand
T cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
The immune system is one of the organs most vulnerable to the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Among the various immunotoxic effects of TCDD, the thymus involution and… Expand
Expression of cytochromes p450 in fetal, infant, and juvenile liver of cynomolgus macaques.
Preclinical data of fetal, infant, and juvenile animals are important for the prediction of drug toxicity in fetuses and children. However, expression of drug-metabolizing enzymes, including… Expand
Regional difference in sulcal infolding progression correlated with cerebral cortical expansion in cynomolgus monkey fetuses
The present study aimed to specify the cerebral sulci developed by cortical expansion in cynomolgus monkey fetuses. The degree of sulcal infolding was evaluated by the gyrification index (GI), which… Expand
Effects of Acclimation/Training on Various Examination Parameters in Monkeys(WORKSHOP 4 : NEW TECHNOLOGY AND EVALUATIONS OF IN VIVO TOXICITY STUDIES)
Nuclear astrophysics projects at the low-energy RI beam separator CRIB
Studies on nuclear reactions relevant for astrophysics have been performed using the radioactive-isotope (RI) beams at the low-energy RI beam separator CRIB, operated by Center for Nuclear Study… Expand
Experimental investigation of linear-chain structured nucleus in 14C
It is a well-known fact that a cluster of nucleons can be formed in the interior of an atomic nucleus, and such clusters may occupy molecular-like orbitals, showing characteristics similar to normal… Expand
Investigation of the Use of Oil-Based Vehicle for Reproductive and Developmental Toxicity Studies in Rabbits : In Use of Olive Oil(General toxicology, Test methods (1), Proceedings of the 32nd Annual…
Study of 19F Levels with Ex = 6.7 - 7.7 MeV by the 15N+α Scattering Experiment
The intense γ-rays from classical novae are emitted due to the β-decay of 18F which is produced by the Hot-CNO cycle. The reaction rate of 18F(p,α)15O affects the prediction of the abundance of 18F.… Expand