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Development in the cynomolgus macaque following administration of ustekinumab, a human anti-IL-12/23p40 monoclonal antibody, during pregnancy and lactation.
BACKGROUND Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of interleukin (IL) 12 and IL-23 and inhibits their pharmacological activity. To evaluate potential effects ofExpand
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Alterations in male infant behaviors towards its mother by prenatal exposure to bisphenol A in cynomolgus monkeys (Macaca fascicularis) during early suckling period
Bisphenol A (BPA) is an environmental chemical with physiological potencies that cause adverse effects, even at environmentally relevant exposures, on the basis of a number of studies in experimentalExpand
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T cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
The immune system is one of the organs most vulnerable to the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Among the various immunotoxic effects of TCDD, the thymus involution andExpand
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Expression of cytochromes p450 in fetal, infant, and juvenile liver of cynomolgus macaques.
Preclinical data of fetal, infant, and juvenile animals are important for the prediction of drug toxicity in fetuses and children. However, expression of drug-metabolizing enzymes, includingExpand
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Regional difference in sulcal infolding progression correlated with cerebral cortical expansion in cynomolgus monkey fetuses
The present study aimed to specify the cerebral sulci developed by cortical expansion in cynomolgus monkey fetuses. The degree of sulcal infolding was evaluated by the gyrification index (GI), whichExpand
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Nuclear astrophysics projects at the low-energy RI beam separator CRIB
Studies on nuclear reactions relevant for astrophysics have been performed using the radioactive-isotope (RI) beams at the low-energy RI beam separator CRIB, operated by Center for Nuclear StudyExpand
Experimental investigation of linear-chain structured nucleus in 14C
It is a well-known fact that a cluster of nucleons can be formed in the interior of an atomic nucleus, and such clusters may occupy molecular-like orbitals, showing characteristics similar to normalExpand
Study of 19F Levels with Ex = 6.7 - 7.7 MeV by the 15N+α Scattering Experiment
The intense γ-rays from classical novae are emitted due to the β-decay of 18F which is produced by the Hot-CNO cycle. The reaction rate of 18F(p,α)15O affects the prediction of the abundance of 18F.Expand
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