Noriko Ide-Iwata

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RATIONALE Embryonic and fetal myocardial growth is characterized by a dramatic increase in myocyte number, but whether the expansion of the myocyte compartment is dictated by activation and commitment of resident cardiac stem cells (CSCs), division of immature myocytes or both is currently unknown. OBJECTIVE In this study, we tested whether prenatal(More)
BACKGROUND Cardiac stem cells (CSCs) delivered to the infarcted heart generate a large number of small fetal-neonatal cardiomyocytes that fail to acquire the differentiated phenotype. However, the interaction of CSCs with postmitotic myocytes results in the formation of cells with adult characteristics. METHODS AND RESULTS On the basis of results of in(More)
RATIONALE Physiological hypertrophy in the developing heart has been considered the product of an increase in volume of preexisting fetal cardiomyocytes in the absence of myocyte formation. OBJECTIVE In this study, we tested whether the mouse heart at birth has a pool of cardiac stem cells (CSCs) that differentiate into myocytes contributing to the(More)
An analysis of the clonality of cardiac progenitor cells (CPCs) and myocyte turnover in vivo requires genetic tagging of the undifferentiated cells so that the clonal marker of individual mother cells is traced in the specialized progeny. CPC niches in the atria and apex of the mouse heart were infected with a lentivirus carrying EGFP, and the destiny of(More)
RATIONALE The adult heart possesses a pool of progenitor cells stored in myocardial niches, but the mechanisms involved in the activation of this cell compartment are currently unknown. OBJECTIVE Ca2+ promotes cell growth raising the possibility that changes in intracellular Ca2+ initiate division of c-kit-positive human cardiac progenitor cells (hCPCs)(More)
c-kit–positive human cardiac progenitor cells (hCPCs) and determine their fate. Methods and Results: Ca oscillations were identified in hCPCs and these events occurred independently from coupling with cardiomyocytes or the presence of extracellular Ca . These findings were confirmed in the heart of transgenic mice in which enhanced green fluorescent protein(More)
s 5285–5294 5285 Differentiation of Cardiac Progenitor Cells Into Myocytes Is Regulated by miR-499 Toru Hosoda, Hanqiao Zheng, Noriko Ide-Iwata, Domenico D’Amario, Konrad Urbanek, Marcello Rota, Jan Kajstura, Piero Anversa, Annarosa Leri; Brigham & Womens Hosp, Boston, MA Cardiac progenitor cells (CPCs) delivered to the infarcted heart generate a large(More)
s 5285–5294 5285 Differentiation of Cardiac Progenitor Cells Into Myocytes Is Regulated by miR-499 Toru Hosoda, Hanqiao Zheng, Noriko Ide-Iwata, Domenico D’Amario, Konrad Urbanek, Marcello Rota, Jan Kajstura, Piero Anversa, Annarosa Leri; Brigham & Womens Hosp, Boston, MA Cardiac progenitor cells (CPCs) delivered to the infarcted heart generate a large(More)
Inflammation driven by immune cells and pro-inflammatory cytokines is implicated in pancreatic β-cell injury, leading to the development of diabetes mellitus. IL-27, a cytokine consisting of IL-27p28 and Epstein-Barr virus-induced gene 3 (EBI3), binds a membrane-bound heterodimeric receptor consisting of the IL-27 receptor α chain (WSX-1) and gp130. IL-27(More)
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