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Estrogen-dependent regulation of the expression of hepatic Cyp2b and 3a isoforms: assessment using aromatase-deficient mice.
- H. Yamada, Noriko Gohyama, S. Honda, T. Hara, N. Harada, K. Oguri
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 1 April 2002
The role of estrogen in the expression and induction of hepatic Cyp2b and Cyp3a isoforms was studied using mice [Ar (-/-) mice] lacking aromatase, a key enzyme for estrogen biosynthesis. The… Expand
FACTORS INVOLVED IN THE INDUCTION OF THE CYP2B SUBFAMILY P450: SEARCH FOR THE TARGET OF INDUCERS USING PHOTOAFFINITY PROBE AND THE ROLE OF STEROLS IN THE INDUCTION
To clarify the mechanism of phenobarbital-mediated increase in the CYP2B subfamily, we tried to detect target(s) of the inducer using azido-PB (AZPB), a photoaffinity ligand, as the probe. Immunoblot… Expand